Congenital Cytomegalovirus (CMV) Clinical Trial
Official title:
Evaluation of the Benefit of Antiviral Treatment With Valganciclovir on Congenital CMV Infection-related Deafness on Hearing and Balance
Congenital cytomegalovirus (CMV) infection is the leading cause of non-genetic neurosensory
deafness and affects 0.5 to 1% of births. Twenty to thirty per cent of children will develop
deafness, some of whom will progress gradually to profound bilateral deafness.
No curative treatment is currently offered for this deterioration in hearing and management
involves the use of a hearing aid or cochlear implant. Many studies describe the utility of
antiviral treatment on the course of the deafness. These mostly involve neonates with
multi-system symptomatic forms of the infection who have been given 6 weeks of ganciclovir
possibly switched to valganciclovir, which has shown benefit in stabilising auditory loss, or
even improvement.
Congenital cytomegalovirus (CMV) infection is the leading cause of non-genetic neurosensory
deafness and affects 0.5 to 1% of births. Twenty to thirty per cent of children will develop
deafness, some of whom will progress gradually to profound bilateral deafness.
No curative treatment is currently offered for this deterioration in hearing and management
involves the use of a hearing aid or cochlear implant. Many studies describe the utility of
antiviral treatment on the course of the deafness. These mostly involve neonates with
multi-system symptomatic forms of the infection who have been given 6 weeks of ganciclovir
possibly switched to valganciclovir, which has shown benefit in stabilising auditory loss, or
even improvement.
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