Biometric Characteristics of the Eye With Microcornea/Microphthalmia &

Status Recruiting

Clinical Trial Summary

Early cataract surgery in microcornea/microphthalmia eyes is essential to prevent amblyopia and improve visual outcomes, including stereopsis. However, despite recent advances in pediatric cataract microsurgical techniques, this surgery remains challenging owing to several intraoperative difficulties attributable to the crowded anterior segment in these small, soft, and poorly developed eyes with shallow anterior chambers, and poor pupillary dilation. In this study the investigator aim to report on the changes in the anterior segment biometric characteristics after cataract extraction in eyes with microcornea/microphthalmia with congenital cataract.

Clinical Trial Description

Eyes with congenital cataract have usually small cornea due to developmental delay of the globe. Recognition of microcornea/microphthalmia may be important as a potential contributor to the development of aphakic glaucoma after cataract surgery. Biometrics characteristics of eyes with m/m before and after removal of the cataractous lens can justify the occurrence of postoperative complications, including glaucoma. Aim of the study: to report on the changes in the anterior segment biometric characteristics after cataract extraction in eyes with microcornea/microphthalmia with congenital cataract. Methods: The study will be a prospective cohorte. Biometry of eligible eyes with congenital cataract in one or both eyes with horizontal cornea diameter less than 11mm and/or axial length less than 2standard deviation for age will be compare to otherwise normal eyes with congenital cataract before and after cataract extraction. The anterior segment biometric characteristics using ultrasound biomicroscopy to measure anterior chamber depth and angle.Cataract surgery will be conducted with or without intraocular lens implantation.Postoperative follow up will be scheduled at the first week and first month, third and sixth months ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04759560
Study type	Observational
Source	Alexandria University
Contact	Gloria Nshokano Simba, MBBch
Phone	01123645112
Email	nshokanosim90@gmail.com
Status	Recruiting
Phase
Start date	July 25, 2020
Completion date	September 1, 2021

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05275764` - Comparison of the Efficacy of Intraocular Lens Optic Capture and In-the-bag Implantation Over 1 Year in Children With Congenital Cataract
Recruiting	`NCT05136209` - Comparison of Posterior Continuous Curvilinear Capsulorhexis With or Without Anterior Vitrectomy	N/A
Recruiting	`NCT03342794` - Morphologic and Biometric Characteristics of Preexisting Posterior Capsule Defects in Congenital Cataracts During the First Year of Life	N/A
Completed	`NCT01297153` - Aphakia Versus Pseudophakia in Children Under 2 Years Undergoing Bilateral Congenital Cataract Surgery	Phase 4
Completed	`NCT04120818` - Inflammatory Cytokines in Congenital Cataract After Lensectomy and Anterior Vitrectomy
Recruiting	`NCT04824963` - Analysis of Related Factors Affecting the Secondary Implantation of Intraocular Lens in Congenital Cataract
Recruiting	`NCT04323982` - Comparison of Traditional Cataract Surgery and Traditional Surgery Combined Triamcinolone Staining	N/A
Completed	`NCT02158325` - Capsulorhexis Size and Capsular Outcome	N/A
Completed	`NCT03621579` - Analysis of Retinal Nerve Fiber Layer and Macular Thickness After Congenital Cataract Surgery	N/A
Recruiting	`NCT03564990` - The Impact of Interactive, Multifaceted Approach Education on Congenital Cataract	N/A
Not yet recruiting	`NCT05282147` - Digital Imaging Versus Ophthalmoscopy	N/A
Not yet recruiting	`NCT03125785` - The Effect of Ophthalmic Solutions on Contact Lenses Used After Surgery for Congenital Cataract Investigated in Vivo	N/A
Recruiting	`NCT04976608` - Relationship of Retinal and Visual Cortex Structure and Visual Acuity After Congenital Cataract Surgery
Completed	`NCT03778086` - Iridocorneal Angle and Anterior Segment Structure in Eyes of Children With Cataract
Recruiting	`NCT03230799` - Comparison of Minimal Invasive Lens Surgery and Traditional Cataract Surgery	N/A
Completed	`NCT02132312` - A Randomized Study in Children Ages Birth Through Three Years Undergoing Unilateral Cataract Extraction With or Without Lens Replacement	Phase 3
Completed	`NCT01136473` - Mechanism of Aphakic and Pseudophakic Glaucoma in Pediatric Patients	N/A
Completed	`NCT03242629` - Comparison Between Oral and Enema of Chloral Hydrate	N/A
Completed	`NCT04077489` - Effects of 23-gauge Lensecotomy Combined With Anterior Vitrectomy on Macular in Children With Congenital Cataract	N/A
Active, not recruiting	`NCT05451745` - Glaucoma Following Pediatric Cataract Surgery

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Biometric Characteristics of the Eye With Microcornea/Microphthalmia and Congenital Cataract Before And After Cataract Extraction

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms