Congenital Cataract Clinical Trial
Official title:
Expression Profile of Inflammatory Cytokines in Congenital Cataract After Lensectomy and Anterior Vitrectomy
NCT number | NCT04120818 |
Other study ID # | yyzhao |
Secondary ID | |
Status | Completed |
Phase | |
First received | |
Last updated | |
Start date | March 4, 2016 |
Est. completion date | February 12, 2017 |
Verified date | September 2019 |
Source | Wenzhou Medical University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
In this prospective study , a cohort of 58 eyes with congenital cataract from Wenzhou medical university was erolled.33 eyes with congenital cataract was after lensectomy and anterior vitrectomy as post-surger group, 26 eyes without cataract surgery as control group. The cytokines of MCP-1, VEGF, IL-1, IFN-γ, IL-1r,IL-4,IL-17, IL-2,IL-5,G-CSF,IL-12, IL-15 was evaluated
Status | Completed |
Enrollment | 59 |
Est. completion date | February 12, 2017 |
Est. primary completion date | February 12, 2017 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 10 Months to 72 Months |
Eligibility |
Inclusion Criteria: aphakic children diagnosed with congenital cataract who underwent
secondary IOL implantation and children with congenital cataract who underwent lensectomy
and anterior vitrectomy and primary IOL implantation Exclusion Criteria:patients with mild cataracts do not require surgery - |
Country | Name | City | State |
---|---|---|---|
China | Eye Hosptial of Wenzhou Medical College | Wenzhou | Zhejiang |
China | Ophthalmology and Optometry Hospital | Wenzhou | Zhejiang |
Lead Sponsor | Collaborator |
---|---|
yin ying zhao |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | inflammatory cytokines | investigate inflammatory microenvironment changes in the aqueous of children after surgery.aqueous humor levels of cytokines, chemokines and growth factors including TGFß2, TNF-a, IL-6, IP10, IL-10, MCP-1, VEGF, IL-1, IFN-?, IL-1r,IL-4,IL-17, IL-2,IL-5,G-CSF,IL-12, IL-15. | before the surgery of secondary IOL implantation |
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