Clinical Trials Logo

Clinical Trial Details — Status: Not yet recruiting

Administrative data

NCT number NCT02930395
Other study ID # CHU-0282
Secondary ID DC-2016-2742
Status Not yet recruiting
Phase N/A
First received October 10, 2016
Last updated October 13, 2016
Start date October 2016
Est. completion date November 2017

Study information

Verified date October 2016
Source University Hospital, Clermont-Ferrand
Contact Patrick LACARIN
Phone 04 73 75 11 95
Email placarin@chu-clermontferrand.fr
Is FDA regulated No
Health authority France: Commission nationale de l'informatique et des libertés
Study type Observational

Clinical Trial Summary

In the past 20 years, the incidence of concussion in direct contact sports has significantly increased. The incidence of concussion in rugby players ranges between 8 to 17 episodes / 1000 playing hours. A recent study published by the French Rugby Federation (FFR) and the National Rugby League (LNR) showed similar results. The latter study was performed analyzing the French "TOP14", which includes 14 teams participating in professional rugby championships. At least two concussions were diagnosed each week. Despite the recent evidence, cognitive assessment remains the only means to determine whether or not players experiencing concussions can return to the game or not.


Description:

The possible evolution of neuro-vascular damage and its biological consequences are currently overlooked. The Head Injury Assessment (HIA) is the current gold standard used by the national Rugby Medical Authorities in accordance with international safety protocols. The HIA protocol relies on neurological or neuropsychological endpoints, potentially subjective or not ensuring sufficient sensitivity. As a result, defining the immediate and long-term pathophysiological consequences of concussions remains challenging. The introduction of an objective blood test to detect the presence and the evolution overtime of neuro-vascular damage could represent a pairing approach filling a sensitive gap in the management of concussed players. Recent evidence has proposed the use of serum biomarkers aiding post-concussion management . Remarkably, serum biomarkers of neuro-vascular functions are currently being used in emergency room settings. Serum levels of the brain protein S100β were demonstrated to have an excellent negative predictive value for neurovascular damage after mild traumatic brain injury (mTBI). Measurement of blood S100β was proposed as a tool to grade TBI, limiting unnecessary CT scan examinations in emergency cases . However, whether the use of serum makers of neuro-vascular damage could benefit the management of sport-related concussion remains unclear. Moreover, repeated concussions have been linked to an increased risk of Alzheimer's disease, Multiple Sclerosis and Parkinson's disease . Serum biomarkers could be of diagnostic and prognostic value, facilitating return to play decisions or predicting lingering risks of cognitive decline.


Recruitment information / eligibility

Status Not yet recruiting
Enrollment 560
Est. completion date November 2017
Est. primary completion date October 2017
Accepts healthy volunteers No
Gender Male
Age group 18 Years and older
Eligibility Inclusion Criteria:

- Players age > 18 years old.

- Players routinely managed by the medical staff of collaborative rugby teams. Availability of clinical data, age, body mass index, brain performance, previous HIA scores, history of concussions.

- Players must agree with all of the aspects of the research. Players must consent for a baseline blood draw before the season starts and follow up sampling after concussions

Exclusion Criteria:

- Adverse players' life style (e.g., alcohol consumption, medications or chronic drug regimens) or pathological conditions associated with abnormal S100ß levels (e.g., S100 genetic variants, cutaneous infections, brain tumor, auto-immune disorders, or hyper-lymphocytosis).

Study Design

Time Perspective: Cross-Sectional


Related Conditions & MeSH terms


Intervention

Procedure:
serum S100B assay


Locations

Country Name City State
France CHU Clermont-Ferrand Clermont-Ferrand

Sponsors (2)

Lead Sponsor Collaborator
University Hospital, Clermont-Ferrand World Rugby Research Unit

Country where clinical trial is conducted

France, 

Outcome

Type Measure Description Time frame Safety issue
Primary significance of S100ß/HIA score in the early management of concussion at day 1 Yes
Primary significance of unveiling novel markers of long-term brain cell damage in rugby players at day 1 Yes
See also
  Status Clinical Trial Phase
Completed NCT03304327 - Mindfulness and Yoga Training for Athletes With Concussion (MYTAC) N/A
Completed NCT05562544 - EEG Diagnostic for Repetitive Sub-concussive Head Impacts
Terminated NCT02988609 - Concussion in Rugby Players: a Pilot Study of Neural Recovery Using fMRI N/A
Completed NCT02710123 - Sub-Threshold Exercise Treatment for Adolescents With Sports Related Concussion N/A
Terminated NCT02100150 - A Safety and Efficacy Study of NNZ-2566 in Patients With Mild Traumatic Brain Injury (mTBI) Phase 2
Active, not recruiting NCT01874847 - PLAY GAME: Post-concussion Syndrome in Youth - Assessing the GABAergic Effects of Melatonin Phase 2/Phase 3
Completed NCT01903525 - DHA For The Treatment of Pediatric Concussion Related to Sports Injury Phase 1
Completed NCT02262507 - Concussion Device Audiological Measures N/A
Enrolling by invitation NCT05948501 - The Effects of Concussion on Gait and Posture in Individuals With Peripheral Vision Loss
Withdrawn NCT02643836 - Pulsed Electromagnetic Field (PEMF) Therapy for Post-Concussive Syndrome N/A
Recruiting NCT03360786 - Primary Prevention of Concussion in Youth Ice Hockey Players N/A
Recruiting NCT03710109 - Evaluation of an EEG Based Concussion System
Completed NCT02278029 - Driving Performance of Teenage Patients With mTBI: a Longitudinal Assessment N/A
Completed NCT02268240 - Care for Post-Concussive Symptoms N/A
Completed NCT02271451 - Q-collar and Brain Injury Biomarkers N/A
Completed NCT02268058 - Use of Ibuprofen and Acetaminophen for Treatment of Acute Headache Post Concussion in Children N/A
Active, not recruiting NCT03608722 - Video Games to Track Cognitive Health N/A
Completed NCT02660164 - A Study to Assess the Effectiveness of the Nautilus BrainPulse™ as an Aid in the Diagnosis of Concussion
Completed NCT02556177 - Advanced MRI Applications for Mild Traumatic Brain Injury-Phase 2 N/A
Completed NCT02344446 - Physical Therapy Intervention for Extended Physical Symptoms After a Sports-related Concussion N/A