Compulsive Behavior Clinical Trial
Official title:
An fMRI Investigation Into Compulsivity in Those Who Have Recovered From Anorexia Nervosa
The investigators will examine compulsivity in those who have recovered from anorexia nervosa, using a multi-modal MRI study. The neural activation of key fronto-striatal areas will be explored using a task which examines set-shifting and reversal-learning, two key components of compulsivity. Additionally, the functional networks displayed during resting-state MRI will be examined between groups, as will the neurochemicals present (using Magnetic Resonance spectroscopy).
The investigators will perform four different MRI (Magnetic Resonance Imaging) scans during
one scanning session on those who have recovered from anorexia nervosa (AN) and healthy
controls.
Participants will come to the Warneford hospital for a 2.5 hour screening visit, which will
consist of questionnaires and interviews to determine their medical and psychiatric history
and current mood, along with a practice of the task they'll do in the scanner. Participants
will also complete two tasks which measure compulsivity and can be correlated with their
brain activity in the scans. The investigators will also go through a scanning safety form
with participants at this time.
Participants will also attend a scanning visit, which will last 1.5 hours. One of the scans
will look at how the brain responds to a particular task. This task will examine aspects of
compulsivity (which is rigidly repeating actions that aren't rewarding) by using face and
house stimuli (see reference 1).
The investigators will also perform a scan when participants are at rest, in order to see if
there are differences in the way areas of the brain connect to each other who used to have
AN. The scientific literature indicates that there may be differences in the some key brain
networks, including one which is thought to be involved in reflection and the self (the
default mode network), which might also be linked to compulsivity (see reference 2).
This study will also further investigate some initial pilot findings using Magnetic Resonance
Spectroscopy, which allows researchers to examine the levels of different neurochemicals in
the brain. It has been found that those with a current diagnosis of AN have lower levels of
glutamate (a key brain chemical) compared to healthy controls, which is a finding we seek to
extend in those who have recovered from AN (see reference 3).
Aims: The investigators aim to see whether there are differences in the brains of those who
have recovered from anorexia compared to those who have never had an anorexia diagnosis. This
will be both at rest, and whilst participants are doing a task which measures compulsivity,
as compulsivity is thought to be a particular risk factor for eating disorders.
Value: If the investigators are able to identify differences, these might reflect underlying
risk factors for eating disorders, which could lead to potential future treatments or
prevention schemes.
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