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Pemetrexed and S-1 in Combination With Bevacizumab in Refractory Colorectal Cancer

Colorectal Neoplasms Clinical Trial

Official title:
A Single Arm, Open Label, Exploratory Study of Pemetrexed and S-1 in Combination With Bevacizumab in Patients Who Have Progressed After Standard Second Line Therapy

Clinical Trial Summary

Limited agents are optional after standard first and second line treatment for mCRC. Only Regorafenib and Fruquintinib are approved in China. PFS of these targeted drugs are not very long. Pemetrexed has shown significant efficacy in advanced lung cancer regarding PFS and OS with controllable toxicity. S-1 has been used in colorectal cancer with promising outcomes. Bevacizumab is also an important monoclonal antibody which could make benefits in treated patients. This study is aimed to explore the efficacy, safety in advanced colorectal cancer failed to standard therapy in Chinese population.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03843853
Study type Interventional
Source The First Affiliated Hospital with Nanjing Medical University
Contact
Status Withdrawn
Phase Phase 2
Start date May 1, 2019
Completion date May 1, 2022
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