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Detect Microsatellite Instability Status in Blood Sample of Advanced Colorectal Cancer Patients by Next-Generation Sequencing

Colorectal Neoplasms Clinical Trial

Official title:
Detect Microsatellite Instability Status in Blood Sample of Advanced Colorectal Cancer Patients by Next-Generation Sequencing

Clinical Trial Summary

The method to analyze the microsatellite instability (MSI) status by next-generation sequencing (NGS) has been established to assess the deficiency of DNA mismatch repair (MMR) system. The aim of our study is to evaluate the feasibility and reliability of this NGS method by testing the circulating tumor DNA (ctDNA) in blood sample of advanced colorectal cancer patients. If the result is positive, the MSI status could be easily learned without the acquisition of tissue samples.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03561350
Study type Observational
Source Shanghai Minimally Invasive Surgery Center
Contact Zhenghao CAI
Phone 86-21-64458887
Email czh12005@rjh.com.cn
Status Recruiting
Phase
Start date September 28, 2017
Completion date September 2018
View Details
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