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A Study of 2nd-line FOLFIRI ± Bevacizumab vs. Irinotecan ± Bevacizumab in mCRC

Colorectal Neoplasms Clinical Trial

Official title:
A Multinational, Randomized, Phase III Study of FOLFIRI With/Without Bevacizumab Versus Irinotecan With/Without Bevacizumab As Second-line Therapy in Patients With Metastatic Colorectal Cancer

Clinical Trial Summary

The primary purpose of this study is to determine the non-inferiority of overall survival FOLFIRI with or without Bevacizumab compared with Irinotecan (CPT-11) with or without Bevacizumab as Second-line therapy in Patient with Metastatic Colorectal Cancer.

Clinical Trial Description

Primary endpoint: Overall survival (OS), Secondary endpoints: Progression-free survival (PFS), Time to treatment failure (TTF), Overall response rate (ORR),Disease Control Rate (DCR), Safety. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03303495
Study type Interventional
Source Sun Yat-sen University
Contact Ruihua Xu, MD, PhD
Phone 87343333
Email xurh@sysucc.org.cn
Status Recruiting
Phase Phase 3
Start date November 14, 2011
Completion date December 31, 2018
View Details
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