Colorectal Neoplasms Clinical Trial
Official title:
A Phase II Clinical Trial Study on Apatinib and XELOX Combination Regimen in the First-line Treatment of End-stage Colorectal Cancer Patients
This study makes an observation over the objective response rate of Apatinib and XELOX combination regimen in the first-line treatment of metastatic colorectal cancer. All the participants will receive the treatment of Apatinib and XELOX combination regimen.
XELOX chemotherapy is an effective therapy for metastatic colorectal cancer as first-line
treatment.
Apatinib is a small-molecule tyrosine kinase inhibitor (TKI) that highly selectively binds
to and strongly inhibits vascular endothelial growth factor receptor 2 (VEGFR-2), with a
decrease in VEGF-mediated endothelial cell migration, proliferation, and tumor microvascular
density. A phase II trail of Apatinib has been demonstrated that Apatinib is safe to treat
the metastatic colorectal cancer and the disease control rate can reach 50%.
;
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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