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A Phase III Study of 2nd-line XELIRI ± Bevacizumab vs. FOLFIRI ± Bevacizumab in mCRC — AXEPT  

Colorectal Neoplasms Clinical Trial

Official title:
A Multinational, Randomized, Phase III Study of XELIRI With/Without Bevacizumab Versus FOLFIRI With/Without Bevacizumab As Second-line Therapy in Patients With Metastatic Colorectal Cancer

Clinical Trial Summary

The primary purpose of this study is to determine the non-inferiority of overall survival XELIRI with or without Bevacizumab compared with FOLFIRI with or without Bevacizumab as Second-line therapy in Patient with Metastatic Colorectal Cancer.

Clinical Trial Description

Primary endpoint: Overall survival (OS), Secondary endpoints: Progression-free survival (PFS), Time to treatment failure (TTF), Overall response rate (ORR),Disease Control Rate (DCR), Relative dose intensity, Safety, and Correlation between UGT1A1 genotype and Safety. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01996306
Study type Interventional
Source Epidemiological and Clinical Research Information Network
Contact
Status Completed
Phase Phase 3
Start date December 2, 2013
Completion date June 30, 2018
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