Colorectal Neoplasms Clinical Trial
Official title:
Vaccination With Autologous Dendritic Cells Pulsed With Allogenous Melanoma Lysate (MelCancerVac) for Treatment of Patients With Advanced Colorectal Cancer
Dendritic cells loaded with tumor antigens induce cytotoxic T-cells which have been proved
capable of killing both melanoma and breast cancer cells. Melanoma and colorectal cancer
cells express some common antigens. Hence it is possible to use melanoma lysate to load the
dendritic cells with tumor antigens similar to the antigens expressed by the patients'
colorectal cancer cells.
The patient receives 10 vaccinations with 14 days between each. The parameters for effect
are changes in tumor/metastasis size measured with computed tomography (CT), decrease in
serum concentration of carcinoembryonic antigen (CEA), performance status measured by the
World Health Organization (WHO) criteria, and Quality of Life.
n/a
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label
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