Development and Validation of a Risk Prediction Model for Preoperative Frailty in Elderly Patients With Colorectal Cancer

Colorectal Cancer Clinical Trial

Official title:

Development and Validation of a Risk Prediction Model for Preoperative Frailty in Elderly Patients With Colorectal Cancer

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05879861
• Other study ID #: ZSKHZ Zi (2022) no. 337
• Status: Recruiting
• Start date: August 1, 2022
• Est. completion date: July 31, 2025

Study information

• Verified date: May 2023
• Source: Zunyi Medical College
• Contact: Yongmei Zhang
• Phone: 13885257269
• Email: hulizym[@]yeah.net
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Fried Scale and its related scales were used to analyze the status and risk factors of preoperative frailty in elderly patients with colorectal cancer. R software was used to construct a risk prediction model for preoperative frailty in elderly patients with colorectal cancer, and its validity and stability were verified in clinical practice.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 364
• Est. completion date: July 31, 2025
• Est. primary completion date: July 31, 2025
• Gender: All
• Age group: 60 Years and older

Eligibility

Inclusion Criteria:

1. patients who met the diagnostic criteria of colorectal cancer in Chinese Guidelines for Diagnosis and Treatment of Colorectal Cancer 2020 Edition and underwent surgery;

2. patients aged =60 years old ;

3. patients who are clearly conscious, able to understand instructions, communicate normally, and complete the physical activity ability test without the assistance of others;

4. patients who gave informed consent and volunteered to participate in the study.

Exclusion Criteria:

1. patients with limb joint disease and lower limb pain;

2. patients with serious heart, liver, kidney diseases could not complete the test;

3. patients with visual impairment and hearing impairment;

4. patients with a history of mental illness or drug dependence;

5. taking antidepressants, levodopa/carbidopa, donepezil hydrochloride and other drugs ;

6. patients who received preoperative radiotherapy and chemotherapy;

7. Patients with hypothyroidism, Parkinson's disease, stroke and other diseases.

Related Conditions & MeSH terms

• Colorectal Cancer
• Colorectal Neoplasms
• Frailty

Locations

Country	Name	City	State
China	Yongmei Zhang	Zunyi	Guizhou

Sponsors (1)

Lead Sponsor	Collaborator
Zunyi Medical College

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Status of frailty	Status of frailty will be assessed by Fried Scale	1 day