Cadonilimab Plus FOLFOXIRI & Bevacizumab as First Line Therapy for

Status Recruiting

Clinical Trial Summary

Clinical Trial Description

Cadonilimab is a first-in-class bispecific, humanized IgG1 antibody targeting PD-1 and CTLA-4, which has the potential to boost immune surveillance in tumors. This was a phase II study of cadonilimab in combination with bevacizumab and FOLFOXIRI as first line therapy in patients with metastatic microsatellite stable (MSS) colorectal cancer. The goal of this clinical trial is to evaluated the efficacy and safety. Cadonilimab (6mg/kg, iv, Q2W, Day1)+irinotecan* 165 mg/m² iv continue for 1.5 hours, D1; oxaliplatin 85 mg/m² iv continue for 2 hours, D1; leucovorin 400 or levoleucovorin 200 mg/m² iv continue for 2 hours, D1; 5-FU 2400 mg/m² cont. inf. 48h; repeat every 2 weeks (Q2W) + bevacizumab （5mg/kg，d 1） ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05839470
Study type	Interventional
Source	Fujian Cancer Hospital
Contact	Rongbo Lin
Phone	0591-83660063
Email	rongbo_lin@163.com
Status	Recruiting
Phase	Phase 2
Start date	November 19, 2023
Completion date	March 1, 2025

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Cadonilimab Plus FOLFOXIRI and Bevacizumab as First Line Therapy for Metastatic MSS Colorectal Cancer

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms