A Study to Investigate LYL845 in Adults With Solid Tumors

Status Recruiting

Clinical Trial Summary

Clinical Trial Description

This is an open-label, multi-center, dose-escalation study with expansion cohorts, designed to evaluate the safety and anti-tumor activity of LYL845, an epigenetically reprogrammed tumor infiltrating lymphocyte (TIL) therapy, in participants with relapsed or refractory (R/R) metastatic or locally advanced melanoma, non-small cell lung cancer (NSCLC), and colorectal cancer (CRC). During the dose-escalation phase of the study (Part A), participants with melanoma will be enrolled. Once a safe recommended Phase 2 dose range (RP2DR) has been established in Part A, enrollment will be expanded (Part B) to include additional participants with melanoma, NSCLC and CRC. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05573035
Study type	Interventional
Source	Lyell Immunopharma, Inc.
Contact	Lauren Levine, MD
Phone	888-707-7917
Email	clinicaltrials@lyell.com
Status	Recruiting
Phase	Phase 1
Start date	December 19, 2022
Completion date	September 2027

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