| Eligibility |
Inclusion Criteria:
- Sign written informed consent before performing any trial related procedures
- = 18 years old
- Histologically or cytologically proven unresectable metastatic colorectal cancer with
liver metastases (AJCC 8th IV)
- Intolerance to second-line therapy, or disease progression during or after second-line
therapy (RECIST V1.1)
- At least one radiographically measurable lesion, according to the RECIST V1.1 criteria
- Patients with asymptomatic brain metastases or stable symptoms after local treatment
were allowed to enroll if they met the following criteria:
- Measurable lesions outside the central nervous system
- No central nervous system symptoms, or symptoms not worsened for at least 2 weeks
- No glucocorticoid therapy was required or glucocorticoid therapy was discontinued
within 7 days before the first study drug administration
- Palliative radiation therapy (including craniocerebral radiation for symptomatic brain
metastases) was permitted, provided that the radiation had ended at least 1 week
before enrollment and that the radiotherapy-related toxicity had recovered to grade 1
or less (CTCAE 5.0, except alopecia).
- ECOG PS scores 0-1
- The expected survival time was >3 months
- Sufficient organ functions, the subjects need to meet the following laboratory
indicators:
- ANC =1.5×10^9/L without the use of granulocyte colony-stimulating factor in the
last 14 days
- Platelets =90×10^9/ without blood transfusion in the past 14 days
- Hemoglobin >9g/dL without blood transfusion or erythropoietin use in the past 14
days
- Total bilirubin =1.5× upper limit of normal (ULN); Or total bilirubin >ULN but
direct bilirubin = ULN
- Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in =2.5×ULN
(ALT or AST =5×ULN allowed in patients with liver metastases)
- Serum creatinine = 1.5 × ULN and creatinine clearance rate (calculated by
Cockcroft-Gault formula) = 60 ml/min
- Good coagulation function, defined as international normalized ratio (INR) or
prothrombin time (PT) =1.5 × ULN
- Normal thyroid function, defined as thyroid stimulating hormone (TSH) within
normal limits. If the baseline TSH was outside the normal range, subjects with
total T3 (or FT3) and FT4 within the normal range could also be enrolled
- The myocardial zymogram is within the normal range (if the investigator
comprehensively determines that the simple laboratory abnormality is not of
clinical significance, it is also allowed to be enrolled)
- Pregnancy test negative and use birth control
Exclusion Criteria:
- Previous treatment with regorafenib
- Previous treatment with anti-PD-L1, anti-PD-L2 drugs, or other drugs that stimulates
or synergistically inhibits T-cell receptors (e.g., CTLA-4, OX-40, CD137)
- Symptomatic or high risk of obstruction, bleeding, perforation, pneumonia (including
noncommunicable pneumonia with previous hormonal therapy and pneumonia in patients
receiving treatment)
- Malignancy other than colorectal cancer diagnosed within 5 years before the first dose
(excluding radical basal cell carcinoma of the skin, squamous carcinoma of the skin,
and/or carcinoma in situ after radical resection)
- currently participating in an interventional clinical study treatment, or has received
another study drug or used a study device within 4 weeks prior to the first dose
- Systemic systemic therapy with proprietary Chinese medicine or immunomodulatory agents
(including thymosin, interferon, and interleukin, except for local use to control
pleural effusion) with anti-tumor indications was received within 2 weeks before the
first dose
- Active autoimmune disease requiring systemic therapy occurred within 2 years before
the first dose. Alternative therapies (e.g., thyroxine, insulin, or physiologic
glucocorticoids for adrenal or pituitary insufficiency) are not considered systemic
therapy
- Receiving systemic glucocorticoid therapy (excluding intranasal, inhaled, or other
local glucocorticoids) or any other form of immunosuppressive therapy within 7 days
before the first dose; Physiological doses of glucocorticoids (=10 mg/day or
equivalent prednisone) are permitted
- Blood transfusion within 7 days before the first dose
- Clinically uncontrollable pleural effusion/abdominal effusion
- Known allogeneic organ transplantation (excluding corneal transplantation) or
allogeneic hematopoietic stem cell transplantation
- Known allergy to the active ingredient or excipient of the study drug
- Not fully recovered from toxicity and/or complications caused by any intervention (=
grade 1 or baseline, excluding fatigue or alopecia) before starting treatment
- HIV 1/2 antibody positive
- Untreated active hepatitis B, subjects who met the following criteria could also be
enrolled:
- HBV viral load <1000 copies/ml (200 IU/ml) before the first dose, subjects should
receive anti-HBV therapy to avoid virus reactivation throughout the study
- Subjects with anti-HBC (+), HBsAg (-), anti-HBs (-), and HBV viral load (-) did
not require prophylactic anti-HBV therapy, but did require close monitoring for
viral reactivation
- Active HCV-infected
- Received live vaccine within 30 days prior to the first dose,Inactivated virus
vaccines for injectable use against seasonal influenza are permitted up to 30 days
before the first dose,live attenuated influenza vaccines administered intranasally not
allowed
- Pregnant or lactating woman
- With any severe or uncontrolled systemic disease
- Other conditions that the subjects are not suitable to participate in this study
according to the judgment of the investigator
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