Liver Transplantation for Non-Resectable Colorectal Liver Metastasis

Colorectal Cancer Clinical Trial

Official title: Liver Transplantation for Non-Resectable Colorectal Liver Metastasis

Status Recruiting

Clinical Trial Summary

The study aims to evaluate the efficacy of liver transplantation in the context of non-resectable colorectal liver metastasis. The primary endpoint is the overall survival in this group of patients while the secondary endpoint is the disease-free survival.

Patients included in this protocol will be evaluated either for whole or partial liver transplantation from deceased or living donors.

Type of different transplantations proposed are as follows:

1. Whole liver graft or partial liver (split) from a deceased donor

2. Partial liver graft retrieved from a deceased donor and orthotopically implanted after having performed a left hepatectomy in the recipient.

3. Partial liver graft retrieved from a deceased donor and heterotopically implanted if total hepatectomy can not be performed.

4. Partial liver graft retrieved from a living donor and orthotopically implanted after having performed total hepatectomy.

5. Partial liver graft retrieved from a living donor and orthotopically implanted after having after having performed a left hepatectomy in the recipient.

6. Partial liver graft retrieved from a living donor and heterotopically implanted if total hepatectomy can not be performed.

In cases 2-3-5-6 total hepatectomy of native liver can be secondarily performed after having achieved a proper graft hypertrophy in order to avoid a small for size syndrome

Clinical Trial Description

n/a

Related Conditions & MeSH terms

• Colorectal Cancer
• Liver Metastasis Colon Cancer
• Liver Neoplasms
• Neoplasm Metastasis
• Neoplasms, Second Primary

• NCT number: NCT05185245
• Study type: Interventional
• Source: IRCCS Azienda Ospedaliero-Universitaria di Bologna
• Status: Recruiting
• Phase: N/A
• Start date: April 1, 2021
• Completion date: March 30, 2030