| Eligibility |
Inclusion Criteria:
PHASE 1 and PHASE 2:
- Subject must be able to understand and sign written informed consent, according to
local guidelines.
- Subject must be =18 years of age at the time of signature of the ICF.
- Subject must have an ECOG PS score of 0 or 1.
- Subject must have adequate organ function, as indicated by the laboratory values in
the protocol
- Women of childbearing potential must have a negative serum pregnancy test before study
entry. Women of non-childbearing potential will have had at least 24 continuous months
of natural (spontaneous) amenorrhea, and an appropriate clinical profile (eg, age
appropriate, history of vasomotor symptoms), or have had hysterectomy, bilateral
salpingectomy or bilateral oophorectomy>6 weeks before screening.
- Male or female subjects: Male subjects with female partners of childbearing potential
and female subjects of childbearing potential are required to use 2 forms of
acceptable contraception, including 1 barrier method, during their participation in
the study and for 4 months after the last dose of CAN04 or for 6 months after the last
dose of the relevant chemotherapies, whatever is longer. Male subjects must also
refrain from donating sperm during their participation in the study and in the period
when contraceptives are required
- Subjects must not have contraindications according to the approved local summary of
product characteristics (SmPC) for the respective components of the SoC
chemotherapies.
PHASE 1 (Dose Escalation)
- Subject has histologically or cytologically confirmed diagnosis of locally advanced
cancer or metastatic cancer. Subjects do not need to have measurable disease per
response evaluation criteria in solid tumours (RECIST) v1.1.
- Subject has a condition where all standard therapeutic options with proven survival
benefit have been exhausted, refused by the subject, or are contraindicated. OR
Subject has a condition where 1 of the 3 study regimens (mFOLFOX, DTX, or G/C) is
considered SoC for the next-line treatment.
- Subject has additional disease characteristics per treatment arm:
- mFOLFOX Arm: All subjects eligible for mFOLFOX can be enrolled. A maximum of 2
previous lines of cytotoxic chemotherapy treatment for metastatic disease is
allowed (targeted agents without cytotoxic effect will not be counted).
- DTX Arm: Subjects eligible to receive DTX as monotherapy for NSCLC can be
enrolled in this treatment arm. No more than 2 lines of prior systemic
anti-cancer therapies for the metastatic disease are allowed. Targeted therapy is
not counted as prior therapy. Subjects who received DTX monotherapy in a prior
line of therapy are not eligible.
- G/C Arm: All subjects eligible for G/C can be enrolled (including first-line
treatments).. Subjects with BTC will be prioritized.
PHASE 2 All treatment arms in Phase 2 (CRC, NSCLC or BTC)
- Subject must have at least 1 measurable lesion as defined by RECIST v1.1. Tumour
lesions that have been irradiated =4 weeks before the start of treatment, and have
subsequently had documented progression, may be chosen as target lesions in the
absence of measurable lesions that have not been irradiated.
- Only applicable after the second interim analysis has been performed: Primary or
metastatic lesion amenable to biopsy and willingness of the subject to undergo a
screening (if no adequate archival tissue is available) and an on-treatment biopsy (as
defined in the protocol). The lesion accessible for biopsy may not be the only target
lesion and should not be located in a previously irradiated field (unless this index
lesion has PD =20% after radiation). The requirement(s) for the screening and/or
on-treatment biopsy and/or archival tissue may be waived by the sponsor for individual
sites and subjects, in particular if tumour locations are not safely accessible, after
discussion and documented agreement between the site and the sponsor´s medical
monitor.
CRC Arm
- Subject has definitive histologically or cytologically confirmed metastatic or locally
advanced adenocarcinoma of the colon or rectum without possibility of locoregional
treatment with curative intention or candidate for curative metastasectomy
- Subject has received at least 2 prior lines of therapy for non-resectable locally
advanced or metastatic CRC and has progressed or is intolerant to those therapies. If
the tumour is microsatellite instability-high, it should have progressed on a previous
immune CPI unless contraindicated, or such therapy is not available to the subject.
Subjects with KRAS wildtype should be eligible to receive mFOLFOX and should have
received anti-EGFR therapy unless contraindicated or not available for the subject.
- Note: For subjects who received adjuvant or neoadjuvant chemotherapy and had
recurrence within 6 months of completion of the adjuvant or neoadjuvant chemotherapy,
the adjuvant or neoadjuvant therapy is counted as the first line of chemotherapy for
the metastatic disease.
NSCLC Arm
- Subject has histologically or cytologically confirmed squamous or non-squamous NSCLC
unresectable stage IIIB/C or stage IV for whom monotherapy DTX treatment is indicated.
- Subject received platinum-based therapy and a programmed cell death protein 1 or
programmed death-ligand 1 inhibitor as prior treatment regimens (unless
contraindicated or such therapy is not available to the subject). Prior CPIs and
chemotherapy may have been administered alone or in combination. No more than 2 prior
lines of cytotoxic chemotherapy containing regimens for the advanced or metastatic
disease are allowed.
Note: Subjects who received DTX monotherapy in a prior line of therapy are not eligible.
- Subjects who received adjuvant or neoadjuvant chemotherapy and had recurrence within 6
months of completion of the adjuvant or neoadjuvant chemotherapy are allowed to count
the adjuvant or neoadjuvant therapy as the first line of chemotherapy for the
recurrent/metastatic disease.
- Subject eligible for mutation-targeted therapies (eg, osimertinib, alectinib,
crizotinib, larotrectinib, capmatinib, pralsetinib) must have exhausted treatment
options for targeted therapies available locally
BTC Arm
- Subject has histopathological or cytological biliary tract carcinoma (intrahepatic or
extrahepatic cholangiocarcinoma, gallbladder cancer, or ampullary carcinoma)
non-resectable, recurrent, or metastatic amenable for G/C treatment indicated as SoC.
- Subject has not received standard systemic anti-cancer therapies neither for
non-resectable locally advanced nor for metastatic disease.
- Note: Subjects who received adjuvant or neoadjuvant chemotherapy and had recurrence
within 6 months after completion of the adjuvant or neoadjuvant chemotherapy are
eligible for the study.
Exclusion Criteria:
- Subject has a known or suspected allergy to study drugs (including chemotherapy
regimens), any of its components.
- Subject has another histologically confirmed cancer different from those described in
inclusion criteria, except for cervical carcinoma in situ, superficial non-invasive
bladder tumour, curatively treated stage I non-melanoma skin cancer, or prostate
cancer subjects curatively treated with surgery or radiation and not receiving
systemic or androgen deprivation therapy. Subjects with a history of another cancer,
different from that described in the inclusion criteria, can be enrolled if the cancer
was curatively treated =5 years ago and non-recurrence has been documented in the past
2 years.
- Subject has uncontrolled or significant heart failure defined as New York Heart
Association Classification III or IV.
- Subjects to receive mFOLFOX or DTX: having peripheral sensory neuropathy Grade =2.
- Subject has QT interval corrected using Fridericia's formula (QTcF) >480 msec at
screening.
- Subjects to receive DTX and CAN04: if they have liver metastases and aspartate
aminotransferase (AST) and/or ALT >1.5 × upper limit of normal (ULN) concomitant with
alkaline phosphatase >2.5 × ULN.
- Subject has uncontrolled brain metastases. Subjects are allowed to be enrolled if
brain metastasis has been previously treated with surgery, and/or stereotactic
radiosurgery and are considered controlled (controlled by the dose =10 mg/day of
prednisone or equivalent) at the time of the first dose of CAN04. For asymptomatic
subjects, without known brain metastases, brain imaging during screening is not
required. Subjects with known brain metastases should have undergone brain imaging in
the frame of the imaging screening procedures.
- Subject has an active severe infection requiring parenteral antibiotics at the time of
enrolment or subjects currently receiving oral antibiotics as a continuation of a
previous course of parenteral antibiotics. Subjects can be enrolled when antibiotic
treatment is complete and if there are no signs of residual infection. Note: Subjects
with BTC who required stent placement should have the procedure completed 2 weeks
before and be free of antibiotics (oral or parenteral) for at least 1 week before
first treatment administration.
- Subject has a history of a relevant autoimmune disease as per assessment of the
investigator or autoimmune disease requiring systemic immunosuppressive therapy (daily
prednisone equivalent doses >10 mg/day).
- Subject is expected to require any other form of systemic or localised anti-neoplastic
therapy while on study (including maintenance therapy with another agent, radiation
therapy, and/or surgical resection).
- Subject has had an allogeneic tissue/solid organ transplant.
- Subject received a live vaccination, etanercept, or other tumour necrosis factor-alpha
inhibitors prior to (within 28 days of first study drug administration) participation
in this study. For severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
vaccines, a wash-out of 2 weeks before first administration of study drug is
recommended.
- Subject had treatment with systemic anti-cancer treatments, or major surgery within 4
weeks before the first dose of study drug or 5 half-lives, whichever is shorter.
Subjects should have recovered from previous treatment toxicity to Grade 1, baseline
(except alopecia and peripheral neuropathy).
- Subject received radiotherapy =4 weeks before the start of treatment (=2 weeks for
palliative irradiation to peripheral tumour lesions, other than for example spine or
pelvis, without increased risk for delayed cytopenias) and has not recovered to Grade
1 or better from related toxicity of such therapy (except for alopecia).
- Subject has known hepatitis B virus surface antigen seropositive or detectable
hepatitis C infection viral load. Note: Subjects who have positive hepatitis B core
antibody or hepatitis B surface antigen antibody can be included but must have an
undetectable hepatitis B viral load.
- Subjects who test positive for human immunodeficiency virus (HIV) are NOT excluded
from this study but must meet the following criteria:
- Have cluster of differentiation 4 (CD4)+ T-cell (CD4+) counts =350 cells/µL.
- Have not had an opportunistic infection within the past 12 months. Subjects on
prophylactic anti-microbials can be included in the study.
- Should be on established anti-retroviral therapy for at least 4 weeks.
- Have an HIV viral load less than 400 copies/mL before enrolment.
- Subject has a known history of any other relevant congenital or acquired
immunodeficiency other than HIV infection.
- Subject has a history or current evidence of any condition, therapy, or laboratory
abnormality that might confound the results of the study, interfere with the subject's
participation for the full duration of the study, or is not in the best interest of
the subject to participate, in the opinion of the treating investigator.
- Subject has known psychiatric or substance abuse disorders that would interfere with
cooperation with the requirements of the study.
- Subject has any medical condition, co-morbidity, physical examination finding,
metabolic dysfunction, or clinical laboratory abnormality that, in the opinion of the
investigator, renders the subject unsuitable for participation in a clinical study due
to high safety risks and/or potential to affect interpretation of results of the
study.
- Subject has known allergy to any of the drugs or excipients in the allocated
treatment.
- Only subjects in the G/C arm: Subjects who, as per applicable local label, due to
hearing impairment or ongoing phenytoin administration, have contraindication for
cisplatin.
mFOLFOX Arm/CRC Arm Exclusion Criteria
- Subjects with clinical laboratory test values at screening below the lower limit of
normal for any of the following electrolytes: potassium, magnesium, corrected or
ionised calcium.
- NOTE: Subjects achieving normal values for these electrolytes with supplements
during the screening period are allowed at the discretion of the investigator.
Serum chemistry documenting normal electrolyte values is required prior to each
dose of oxaliplatin.
- Subjects with congenital long QT syndrome or a history of ventricular arrhythmias,
including bradyarrhythmia (<50 beats per minute).
- Subjects with existing uncompensated heart disease: myocardial ischaemia or early (up
to 4 weeks) post-infarction status, congestive heart failure, left ventricular
hypertrophy, cardiomyopathy, conduction disorder within 6 months before enrolment.
- Subjects with dihydropyrimidine dehydrogenase (DPD) deficiency or who have been
treated within 4 weeks of first dose of study treatment with potent DPD inhibitors
(eg, brivudine, sorivudine). Subjects who previously received 5-FU without toxicity
that can be correlated with DPD deficiency do not need to be tested
- Subjects with pernicious anaemia or other anaemias due to vitamin B12 deficiency that
cannot be corrected before the first dose of mFOLFOX.
|
