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Clinical Trial Summary

Data from a prior phase II study of single agent cabozantinib in metastatic, refractory colorectal cancer (NCT03542877) combined with the compelling preclinical data in colorectal mouse models utilizing cabozantinib combined with nivolumab have led to this concept for a clinical trial to combine cabozantinib and nivolumab in patients with metastatic MSS CRC in the third line setting and beyond.


Clinical Trial Description

This is an open-label, single-arm, 2-stage, phase II study of cabozantinib in combination with nivolumab in patients with refractory metastatic CRC. Up to 46 evaluable patients will be treated with cabozantinib 40 mg orally daily in combination with nivolumab 480 mg IV every 28 days. One cycle is defined as 28 days. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04963283
Study type Interventional
Source University of Colorado, Denver
Contact
Status Active, not recruiting
Phase Phase 2
Start date June 23, 2021
Completion date February 9, 2026

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