Colorectal Cancer Clinical Trial
Official title:
A Prospective Study on the Conversion Therapy of Ras / BRAF Wild Type Right-sided Colon Cancer Patients With Initially Unresectable Liver Metastases: Standard Chemotherapy Plus Cetuximab VS. Standard Chemotherapy Plus Bevacizumab
The prognosis of patients with metastatic right-sided colon cancer is worse than that of
patients with metastatic left-sided cancer. Different guidelines have different
recommendations on specific conversion therapy for colorectal liver metastases. The United
States NCCN guidelines do not recommend standard chemotherapy combined with anti EGFR
monoclonal antibody for patients with right colon cancer. The European ESMO guidelines
recommend that patients with Ras / BRAF wild-type right-sided colon cancer should first
consider three drugs ± bevacizumab, but considering the objective response rate results,
standard chemotherapy + anti EGFR monoclonal antibody is still one of the choices. China CSCO
guidelines recommend standard chemotherapy ± bevacizumab, and also recommend standard
chemotherapy + cetuximab for patients with right-sided colon cancer.
Therefore, the targeted therapy for RAS / BRAF wild-type metastatic right colon cancer is
still controversial. Therefore, we are ready to carry out the clinical trial of cetuximab and
bevacizumab in conversion therapy for RAS / BRAF wild-type metastatic right colon cancer. The
conversion resection rate is the primary point, and the objective response rate,
perioperative safety and long-term survival are the secondary points.
n/a
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