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Safety and Preliminary Efficacy of SNK01 in Combination With Trastuzumab or Cetuximab in Subjects With Advanced HER2 or EGFR Cancers

Colorectal Cancer Clinical Trial

Official title:
A Phase 1/2a, Open-Label, Multi-Center Study Evaluating the Safety and Anti-Tumor Activity of Ex Vivo Expanded, Autologous Natural Killer Cells (SNK01) in Combination With Trastuzumab or Cetuximab in Subjects With Advanced/Metastatic HER2- or EGFR-Expressing Cancers

Clinical Trial Summary

The purpose of the Phase 1/2a study is to evaluate the safety and tolerability of SNK01 in combination with trastuzumab or cetuximab in order to determine the maximum tolerated dose (MTD)/recommended Phase 2 dose (RP2D), and the preliminary efficacy for each combination regimen.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

  • Advanced Solid Tumor
  • Bladder Cancer
  • Breast Neoplasms
  • Carcinoma, Non-Small-Cell Lung
  • Carcinoma, Squamous Cell
  • Cervical Cancer
  • Colorectal Cancer
  • Colorectal Neoplasms
  • EGF-R Positive Non-Small Cell Lung Cancer
  • Endometrial Neoplasms
  • Endometrium Cancer
  • Esophageal Cancer
  • Esophageal Neoplasms
  • Head and Neck Squamous Cell Carcinoma
  • HER-2 Protein Overexpression
  • HER2-positive Breast Cancer
  • HER2-positive Gastric Cancer
  • Lung Neoplasms
  • Metastatic Cancer
  • Neoplasm Metastasis
  • Non Small Cell Lung Cancer
  • Ovarian Cancer
  • Ovarian Neoplasms
  • Pancreatic Cancer
  • Pancreatic Neoplasms
  • Sarcoma
  • Squamous Cell Carcinoma of Head and Neck
  • Stomach Neoplasms
  • Triple Negative Breast Cancer
  • Triple Negative Breast Neoplasms
  • Urinary Bladder Neoplasms
  • Uterine Cervical Neoplasms
Clinical Trial Details
NCT number NCT04464967
Study type Interventional
Source NKGen Biotech, Inc.
Contact
Status Withdrawn
Phase Phase 1/Phase 2
Start date March 2021
Completion date February 2023
View Details
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