Emergency Curative Resection of Colorectal Cancer

Colorectal Cancer Clinical Trial

Official title:

Emergency Curative Resection of Colorectal Cancer, Do it With Caution. A Comparative Case Series

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04288284
• Other study ID #: 0302761
• Status: Completed
• Start date: January 2015
• Est. completion date: February 2020

Study information

• Verified date: February 2020
• Source: University of Alexandria
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The feasibility and efficacy of emergency curative resection of complicated colorectal cancer is still controversial. This prospective study aim is to assess surgical and oncologic outcomes after emergency compared to elective curative resection of colorectal cancer

Description:

60 consecutive patients presented with complicated colorectal cancer managed by emergency surgery were included and compared to another 155 consecutive patients admitted during the same period with uncomplicated colorectal cancer managed by elective surgery. Both groups were compared regarding curative resection rate, early postoperative mortality and morbidity, 3-years tumor recurrence and survival rates.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 215
• Est. completion date: February 2020
• Est. primary completion date: December 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

• All patients presented with Potentially operable colorectal cancer

• No clinical or radiological evidence of metastatic disease

Exclusion Criteria:

• Patients received preoperative chemoradiation

• Patients with clinical or radiological evidence of metastatic disease

• Patients with intraoperative evidence of metastatic disease

• Patients with intraoperative evidence of irresectable disease

• Patients with incomplete follow up

Related Conditions & MeSH terms

• Colorectal Cancer
• Colorectal Neoplasms
• Emergencies
• Oncologic Complications and Emergencies

Intervention

Procedure:
• Curative resection of colorectal cancer

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
University of Alexandria

References & Publications (3)

Biondo S, Martí-Ragué J, Kreisler E, Parés D, Martín A, Navarro M, Pareja L, Jaurrieta E. A prospective study of outcomes of emergency and elective surgeries for complicated colonic cancer. Am J Surg. 2005 Apr;189(4):377-83. — View Citation

Ghazi S, Berg E, Lindblom A, Lindforss U; Low-Risk Colorectal Cancer Study Group. Clinicopathological analysis of colorectal cancer: a comparison between emergency and elective surgical cases. World J Surg Oncol. 2013 Jun 11;11:133. doi: 10.1186/1477-7819-11-133. — View Citation

Kim J, Mittal R, Konyalian V, King J, Stamos MJ, Kumar RR. Outcome analysis of patients undergoing colorectal resection for emergent and elective indications. Am Surg. 2007 Oct;73(10):991-3. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Adequate oncologic resection	Negative resection margins + adequate lymphadenectomy ( Lymph Nodes retrieved > 12)	histopathological assessment of surgical specimens within 2 weeks postoperative
Primary	early postoperative mortality after curative resection of colorectal cancer	early death due to cause related to surgery	within 90 days after surgery
Primary	early postoperative morbidity after curative resection of colorectal cancer	surgery-related complications	within 90 days after surgery
Secondary	Tumor recurrence	either local or distant	By the end of the 3 years follow up period
Secondary	Disease free survival	% of patients survived without recurrence	By the end of the 3 years follow up period
Secondary	Overall survival	% of all patients survived either with or without recurrence	By the end of the 3 years follow up period