Colorectal Cancer Clinical Trial
Official title:
Nutritional Support and Its Influence on the Reduction of Muscle Strength, Muscle Mass and Self-sufficiency in Patients Undergoing Surgical Treatment of Colorectal Cancer
According to available data, 30-60% of patients are undernourished at hospital admission. The
significance of the perioperative nutrition has already been studied in the 1930s. The
outcomes of published studies demonstrated that patients with basic nutrient deficiencies
have a higher frequency of postoperative complications and have a significantly longer
recovery period.
The main aim of the this prospective clinical trial is to evaluate the loss of muscle mass
and strength of the patient, the self-sufficiency and the possibility of returning to normal
activities, in relation to pre-operatively served nutritional supplements in patients
undergoing elective surgery for colorectal cancer.
Malnutrition is a pathological condition of the body caused by a deficiency of essential
nutrients. The main feature is protein deficiency, which is caused by disruption of protein
and energy balance and needs in the body. According to available data, 30-60% of patients are
undernourished at hospital admission. The significance of the perioperative nutrition has
already been studied in the 1930s. The outcomes of published studies demonstrated that
patients that patients with basic nutrient deficiencies have a higher frequency of
postoperative complications and have a significantly longer recovery period.
In 1992, a randomized clinical trial "Peri-operative nutritional support" showed that 85% of
hospitalized seniors have malnutrition. The study demonstrated the need for nutritional
training to prevent complications and clearly showed a relationship between malnutrition and
reconvalescence length and mortality rate. In 2004, another large randomized trial
("Randomized clinical trial of the effects of preoperative and post operative oral
nutritional supplements on clinical course and cost of care") confirmed the relationship
between malnutrition and the incidence of all perioperative complications. Several other
studies, which have been realized within the last decade, confirmed the positive effect of
good nutritional condition on postoperative morbidity and mortality.
To the best of the investigator's knowledge, all clinical trials dealing with the issue of
preoperative nutrition (published up to now) were primarily focused on the research of the
relationship between malnutrition and the frequency of postoperative complications.
The main aim of the this prospective clinical trial is to evaluate the loss of muscle mass
and strength of the patient, the self-sufficiency and the possibility of returning to normal
activities, in relation to pre-operatively served nutritional supplements in patients
undergoing elective surgery for colorectal cancer.
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