Colorectal Cancer Clinical Trial
Official title:
A Phase I/II Study for the Safety and Efficacy of Panitumumab in Combination With TAS-102 for Patients With RAS (KRAS, NRAS) Wild-type, Unresectable, Advanced/Recurrent Colorectal Cancer
The purpose of this study is to evaluate the combination of panitumumab and Triflridine/Tipiracil (FTD/TPI; TAS-102) in patients with RAS wild-type metastatic colorectal cancer (CRC) refractory to standard chemotherapy (oxaliplatin, fluoropyrimidines, irinotecan and angiogenesis inhibitors).
The purpose of this study is to evaluate the combination of panitumumab and TAS-102 in
patients with RAS wild-type metastatic colorectal cancer (CRC) refractory to standard
chemotherapy (oxaliplatin, fluoropyrimidines, irinotecan and angiogenesis inhibitors).
Patients who are judged eligible for the study based on the inclusion and exclusion criteria
will be received panitumumab (6 mg/kg) every 2 weeks and TAS-102 (35 mg/m² given orally twice
a day in a 28-day) in 2-week cycle of 5 days of treatment followed by a 2-day rest period,
and then a 14-day rest period.
A maximum of 58 participants will be enrolled.
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