Colorectal Cancer Clinical Trial
Official title:
Simultaneous Detection of Somatic Quantitative Molecular Alterations Using the Qantitative Multiplex Pcr of Short Fluorescent Fragments Method (QMPSF) in Stage II-III Colon Cancer: a Prospective Study
Lymph node involvement remains the main criteria for postoperative chemotherapy in patients
with colon cancer (CC) without distant metastasis. To date, the prognostic value of the
somatic quantitative molecular alterations such as loss or gain of genomic region is not
established in CC.
AIMS & METHODS: Using the one-step screening method based on the Quantitative Multiplex PCR
of Short fluorescent Fragments (QMPSF), we aimed to assess the prognostic role of the
simultaneous detection of main quantitative somatic alterations in stage II-III CC.
Patients and Methods. We enrolled and collected all baseline characteristics of patients
operated for a stage II-III CC with storage frozen tissues. The QMPSF was based on a
simultaneous amplification of 9 selected target genomic sequences from literature: DCC
(18q21); EGFR (7p12); P53 (17p13.1); BLK (8p23-p22); c-myc (8q24.12); APC (5q22.2); ERBB2
(17q12); STK6 (20q13.31); NR21 (14p11.1) and two control: DCOHM (5q31.1); HMBS (11q23.3).
Comparison of each amplicon electropherograms obtained from tumour vs normal peritumoral
tissue allowed us to identified gain or loss genomic region. The primary end-point was the
local and/or distant recurrence and relation between clinical and single or combined
molecular alterations and recurrence were evaluated.
n/a
Intervention Model: Single Group Assignment, Masking: Open Label
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