Colorectal Cancer Clinical Trial
Official title:
NK Activity Modulation by Intravenous Lidocaine During Laparoscopic Colorectal Surgery
Surgical resection is the best treatment option for colorectal cancer. Despite this radical
approach, recurrences within five years are still common. Several authors have proposed that
the immunosuppressive state surrounding the perioperative period was a key element of cancer
cells spread.
A particular subtype of T lymphocytes, the Natural Killer cells (NKs), is the main actor of
the innate immune system. Several factors of the perioperative period can reduce activity of
NKs such as stress, pain, opioids and general anaesthetics.
Lidocaine is a local anaesthetic that has been widely used intravenously for abdominal
surgeries. Intravenous lidocaine has been shown to reduce pain scores, morphine consumption,
ileus time and length of stay in major colorectal surgeries. It reduced markers of systemic
inflammation as well.
The authors hypothesize that the use of intravenous lidocaine during laparoscopic surgeries
for colorectal cancer resection will preserve NKs activity.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver), Primary Purpose: Basic Science
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