Chemoradiotherapy for Patients With Oligometastatic Colorectal Cancer

Colorectal Cancer Clinical Trial

— OLGA  

Official title:

Capecitabine and Bevacizumab With Radiotherapy After 3-6 Months Chemotherapy for Patients With Oligometastatic Colorectal Cancer (OLGA Trial)

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT01759238
• Other study ID #: OLGA
• Secondary ID: 2011-005296-16
• Status: Terminated
• Phase: Phase 2
• Start date: May 2013
• Est. completion date: October 2014

Study information

• Verified date: June 2022
• Source: Universitätsklinikum Hamburg-Eppendorf
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study tries to evaluate the role of chemoradiation with capecitabine and bevacizumab in oligometastatic patients neither being progressive nor resectable after chemotherapy.

Description:

Combining chemoradiation with an antiangiogenic agent has a strong biological rationale, and preclinical studies consistently show an increase in radiosensitization with combined treatment. It is well described that hypoxia or HIF-1 expression is associated with a lower radiation response and progression in solid tumors. Radiation itself induces transient tumor hypoxia, which in turn stimulates VEGF production and VEGFR-2 expression what may also serve as a paracrine proliferative stimulus that promotes out-of-field growth. The combination of radiotherapy with an antiangiogenic agent (e.g. bevacizumab) thus offers the potential to enhance the effect of radiation, and avoid further spread of disease. Furthermore, targeting tumor vasculature improves the delivery of cytotoxic drugs (e.g. capecitabine) leading to increased efficacy of chemoradiation. Combination with cytotoxic drugs could additionally limit treatment-induced hypoxia (Senan and Smit 2007; Mazeron, Anderson et al. 2011).

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 1
• Est. completion date: October 2014
• Est. primary completion date: October 2014
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

1. Patients with histologically confirmed diagnosis of stage IV (UICC) colorectal cancer

2. Oligometastatic disease, defined as at least one measureable lesion with size > 1cm (RECIST v1.1) to a maximum of 3 sites and 5 lesions suitable for radiotherapy according to the dose constraints for normal tissue

3. Patients being neither progressive nor resectable after 3-6 months of first line chemotherapy (combination chemotherapy, at least chemo-doublet) with bevacizumab

4. maximum treatment interruption after induction therapy of 6 weeks

5. ECOG performance status = 1

6. Life expectancy > 3 months

7. Age = 18 years

8. Haematologic function: ANC = 1.5 x 109/L, platelets = 75 x109/L

9. INR < 1.5 within 7 days prior to starting study treatment. aPTT < 1.5 ULN within 7 days prior to starting study treatment

10. adequate liver function as measured by serum transaminases (AST & ALT) = 5 x ULN and a total bilirubin =1.5 x ULN

11. adequate renal function: serum creatinine = 1.5 x ULN

12. signed, written informed consent

13. ability to swallow tablets

Exclusion Criteria:

1. treatment with any other investigational agent, or participation in another clinical trial within 30 days prior to entering this study

2. prior radiotherapy for metastatic lesions (prior radiotherapy for primary tumor allowed if followed by complete resection and no sign for local recurrence at the time of enrolment)

3. Pre history or evidence upon physical/neurological examination of CNS disease (unrelated to cancer) (unless adequately treated with standard medical therapy) e.g. uncontrolled seizures

4. fertile women (< 2 years after last menstruation) and women of childbearing potential unwilling or unable to use effective means of contraception (oral contraceptives, intrauterine contraceptive device, barrier method of contraception in conjunction with spermicidal gel or surgically sterile)

5. pregnancy or lactation

6. Positive serum pregnancy test within 7 days of starting study treatment in pre-menopausal women and women < 2 years after the onset of menopause. Note: a negative test has to be reconfirmed by a urine test, should the 7-day window be exceeded.

7. Past or current history (within the last 2 years prior to treatment start) of other malignancies except metastatic colorectal cancer (patients with curatively treated basal and squamous cell carcinoma of the skin or in situ carcinoma of the cervix are eligible).

8. Known DPD-insufficiency

9. Active inflammatory bowel disease or other bowel disease causing chronic diarrhea (defined as > 4 loose stools per day)

10. Serious, non-healing wound, ulcer or bone fracture.

11. Evidence of bleeding diathesis or coagulopathy.

12. Urine dipstick for proteinuria >2+. If urine dipstick is 2+, 24-hour urine must demonstrate 1 g of protein in 24 hours for patient to be eligible.

13. Major surgical procedure, open biopsy or significant traumatic injury within 28 days prior to first treatment with study medication.

14. Clinically significant cardiovascular disease, for example CVA, myocardial infarction (£ 12 months before treatment start), unstable angina pectoris, NYHA Class II CHF, arrhythmia requiring medication, or uncontrolled hypertension.

15. Evidence of any other disease, metabolic dysfunction, physical examination finding or laboratory finding giving reasonable suspicion of a disease or condition that contraindicates the use of an investigational drug or puts the patient at high risk for treatment-related complications.

16. Concomitant therapy with sorivudin or chemical analogues like brivudin

17. Known hypersensitivity or contraindication to the drugs used in the trial (eg:

capecitabine, bevacizumab)

18. Inability or unwillingness to comply with the protocol.

Related Conditions & MeSH terms

• Colorectal Cancer
• Colorectal Neoplasms
• Metastases
• Neoplasm Metastasis

Intervention

Drug:
• Capecitabine
825mg/m2 per os bid
• Bevacizumab
7.5 mg/kg

Radiation:
• Radiotherapy
(conventional or intensity-modulated and image-guided radiotherapy)

Locations

Country	Name	City	State
Germany	University Hospital Hamburg-Eppendorf	Hamburg

Sponsors (1)

Lead Sponsor	Collaborator
Universitätsklinikum Hamburg-Eppendorf

Country where clinical trial is conducted

Germany, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Progression free survival rate	Progression free survival rate at 12 months after start of induction treatment (PFSR@12)	12 months
Secondary	Time to progression (TTP) in 2 cohorts	Time to progression (TTP) in 2 cohorts: regards only progression within (TTPir) and; in- and outside irradiated areas ("overall" TTP)	24 months
Secondary	Overall Response Rate	Efficacy of the investigational therapy shown by the Overall Response Rate (CR and PR) according to RECIST v1.1	12 months
Secondary	Overall survival (OS)		36 months
Secondary	Quality of life (QoL)	Quality of life using the EORTC QLQ-C30 and the module CR29	12 months
Secondary	Prognostic and predictive value of PET scan	Prognostic and predictive value of PET scan at baseline and at 2 months after chemoradiation	at baseline and 2 months after chemoradiation
Secondary	Toxicity	Number of adverse events, according to NCI CTCAE v4.0)	12 months