Colorectal Cancer Clinical Trial
Official title:
A Random, Open, Dose Finding and Pharmacokinetics/Pharmacodynamics(PK/PD) Phase II Study of Apatinib Tablets in the Treatment of Advanced Colorectal Cancer
RATIONALE:
Apatinib is a tyrosin-inhibitor agent targeting at vascular endothelial growth factor
receptor (VEGFR), and it's anti-angiogenesis effect has been viewed in preclinical tests.
The investigators' phase I study has shown that the drug's toxicity is manageable.
PURPOSE:
1. Studying how well Apatinib works in treating patients.
2. Finding the efficacy and safety of 500 mg or 750mg Apatinib.
3. Pharmacokinetics/Pharmacodynamics(PK/PD).
4. Exploring new outcome measures of antiangiogenic drugs.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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