Colorectal Cancer Clinical Trial
Official title:
Assessment of Variation of PKA and Other Molecular Markers in Patients Undergoing Resection of Colon Cancer Metastases
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may
help doctors identify and learn more about biomarkers related to cancer.
PURPOSE: This research study is looking at biomarkers in tissue samples from patients with
metastatic colon cancer.
OBJECTIVES:
- Determine the effect of surgical resection, in terms of physiological stress, on levels
of tumor markers such as protein kinase A (PKA) expression in patients with metastatic
colon cancer.
- Estimate variation among patients of baseline tumor markers in tumor tissue and sera.
- Correlate markers in tumor tissues with that in sera in these patients.
- Establish a tissue bank of these specimens for future studies.
OUTLINE: Biopsy and surgical specimens are obtained before and during standard surgery
(patients may have had tumor tissue obtained before study entry and stored). Serum samples
and tumor tissue are analyzed by immunohistochemistry and western blot. Tumor markers (such
as PKA expression) are determined and marker levels are measured in serum samples and
tissues.
PROJECTED ACCRUAL: Approximately 30 patients will be accrued for this study.
;
Observational Model: Case-Only, Time Perspective: Prospective
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