Colorectal Cancer Clinical Trial
Official title:
Investigation of Thioredoxin-1 Family Protein Expression in Rectal Cancer
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may
help doctors learn more about changes that occur in DNA and identify biomarkers related to
cancer. It may also help doctors predict how patients will respond to treatment.
PURPOSE: This research study is looking at protein expression in tumor tissue samples from
patients with stage II or stage III rectal cancer enrolled in clinical trial SWOG-9304.
OBJECTIVES:
- Determine expression levels of thioredoxin-1 (Trx-1), thioredoxin-interacting protein
(TXNIP), and hypoxia inducible factor-1 alpha (HIF-1α) in paraffin-embedded resected
tumor tissue samples from patients with stage II or III rectal cancer enrolled in
clinical trial SWOG-9304.
- Determine if there is a correlation between Trx-1 and TXNIP expression and HIF-1α
expression.
- Correlate expression of these proteins with tumor stage, disease-free survival, overall
survival, and risk of recurrence.
- Determine interactions for patient age, performance status, and type of therapy
received on clinical trial SWOG-9304.
OUTLINE: This is a multicenter study.
Paraffin-embedded resected tumor tissue samples are analyzed for protein expression levels
(thioredoxin-1, thioredoxin-interacting protein, and hypoxia inducible factor-1 alpha) by
tissue microarray and immunostaining.
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Observational Model: Cohort, Time Perspective: Retrospective
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