Colorectal Cancer Clinical Trial
Official title:
Clinical Significance of Genetic Markers in Colon Cancer
RATIONALE: Determination of genetic markers for colorectal cancer may improve the
identification of patients who are at highest risk for relapse.
PURPOSE: This clinical trial is studying the importance of genetic markers for detecting
relapse in patients with colorectal cancer.
OBJECTIVES:
- Determine the clinical and pathologic significance of unstable DNA elements in
colorectal cancer (tumor microsatellite instability).
- Determine the clinical and pathologic significance of loss of heterozygosity for
chromosomes 5, 8, 17, and 18 (as the primary targets) and of chromosomes 1, 14, and 22
(as the secondary targets) in colorectal cancer.
OUTLINE: DNA is examined for unstable elements (microsatellite instability and loss of
heterozygosity) by analyzing at least 10 separate (CA)n-repeats localized to 5 separate
chromosomes (5q, 8p, 15, 17p, and 18q). Loss of heterozygosity is analyzed for at least four
chromosomal arms (5q, 8p, 17p, and 18q) and later other chromosomes (e.g., 1, 14, and 22).
Immunohistochemistry is used to test for the presence or absence of the genes involved in
DNA mismatch repair (hMLH1 and hMSH2).
Patients do not receive the results of the genetic testing and the results do not influence
the type or duration of treatment.
PROJECTED ACCRUAL: This study will accrue up to 708 specimens.
;
Observational Model: Case-Only, Time Perspective: Prospective
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