Colonic Polyp Clinical Trial
Official title:
Accuracy of aCeTIC Acid to Predict Histopathology of Colonic Polyps
The use of acetic acid in the characterization of polyps, produces a homogeneous white
staining in sessile serrated adenomas, but not in tubular or tubulo-villous adenomas, a
simple approach to predict polyp histopathology.
To determine the diagnostic accuracy of the use of acetic acid on tubular and serrated
adenomas, during colonoscopy, a prospective diagnostic accuracy study was designed, taking as
gold standard the pathological anatomy of the resected polyps.
Polyps found during a colonoscopy with suspicion of sessile serrated adenomas or
tubular/tubulo villous will be included.
In our experience tubular or tubulovillous adenomas with acetic acid have the same behavior
as normal colonic mucosa. When sprayed with acetic acid they stain white, as well as the
surrounding mucosa, but with a subsequent rapid loss of the effect. In contrast, serrated
adenomas maintain an "aceto-whitening" reaction even though the surrounding normal mucosa
loses staining.
The objectives are to determine the sensitivity and specificity, positive and negative
probability coefficients of the positive or negative aceto-whitening reaction on serrated
adenomas and tubular-tubulo-villous adenomas.
To determine the diagnostic accuracy of the use of acetic acid on tubular, tubulo-villous and
serrated adenomas a prospective diagnostic accuracy study was designed considering the gold
standard as the pathological anatomy of resected polyps.
As independent variables the presence or absence of aceto-whitening reaction after staining
and the diagnostic impression of the endoscopist without acetic acid are considered. The
presence or not of the aceto-whitening reaction will be evaluated, understanding it as the
persistence of white staining of the polyp at one minute or three minutes, standing out from
the surrounding mucosa.
In case of positive staining it will be considered homogeneous if the staining is uniform on
the surface of the polyp or heterogeneous if it is done irregularly.
Place: German Hospital, endoscopy unit.
Data analysis: the data collected in double-entry tables will be captured to obtain the same
sensitivity, specificity and positive or negative probability coefficients.
Sample size: 100 polyps.
Estimated duration: 1 month
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