Colonic Polyp Clinical Trial
Official title:
Peripheral Blood Telomere Length as a Biomarker of Advanced Colorectal Adenomas
The aim of this study is to develop a blood test to determine which patients are at risk for pre-cancerous colon polyps (ACPs: Advanced Colon Polyps). The telomere length of peripheral blood lymphocytes (PBLs) can be measured from a blood sample. Mechanistic pathways and the investigator's preliminary data support PBL telomere length as a biomarker for ACPs. The long-term goal of this project is to decrease deaths from colon cancer by using a blood test to target colonoscopy for those patients who are at high risk for pre-cancerous polyps.
Telomeres are the repetitive DNA sequences that cap both ends of chromosomes. Shortening of
peripheral blood lymphocyte (PBL) telomeres has been associated with renal and other
cancers. The investigators' preliminary data shows an association between shorter PBL
telomere length and ACPs.
I. Specific Aims
1. Develop a DNA and data repository from individuals with advanced colon polyps (ACPs)
and controls
2. Confirm that individuals 50 to 60 years of age with ACPs tend to have shorter
peripheral blood lymphocyte (PBL) telomeres than those without ACPs
3. Identify a potential optimal PBL telomere length cut-off to differentiate between
individuals with ACPs and those without for evaluation in a larger scale study
The over reaching long term goal is to decrease disease and death from colorectal cancer
(CRC) using a biomarker strategy to target colonoscopy to those at higher risk.
;
Observational Model: Case Control, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03272945 -
Linked-color Imaging for the Detection of Colorectal Flat Lesions
|
N/A | |
| Recruiting |
NCT06062095 -
Computer Aided Diagnosis (CADx) for Colorectal Polyps Resect-and-Discard Strategy
|
N/A | |
| Not yet recruiting |
NCT02688699 -
Additive Hemostatic Efficacy of EndoClot After EMR or ESD in the Gastrointestinal Tract
|
Phase 4 | |
| Active, not recruiting |
NCT03962868 -
Endoscopic Submucosal Dissection (ESD) Versus Endoscopic Mucosal Resection (EMR) for Large Non Pedunculated Colonic Adenomas: a Randomized Comparative Trial
|
N/A | |
| Not yet recruiting |
NCT05776381 -
The Impact of a Patient Decision Aid on Treatment Choices for Patients With an Unexpected Malignant Colorectal Polyp
|
Phase 2 | |
| Recruiting |
NCT04157803 -
Accuracy of aCETIC Acid to Predict Histopathology of Colonic Polyps
|
N/A | |
| Completed |
NCT03758872 -
CUFF-assisted Colonoscopy vs Standard Colonoscopy
|
||
| Recruiting |
NCT05870332 -
Nationwide Study of Artificial Intelligence in Adenoma Detection for Colonoscopy
|
||
| Completed |
NCT03690297 -
Linked Color Imaging (LCI) for Colorectal Adenoma Detection
|
N/A | |
| Recruiting |
NCT04149184 -
Computer-aided Detection Device in Standard Colonoscopy
|
N/A | |
| Active, not recruiting |
NCT03865537 -
Cold Snare Endoscopic Mucosal Resection Trial
|
N/A | |
| Recruiting |
NCT05099432 -
The CARMA Technique Study
|
N/A | |
| Withdrawn |
NCT04778566 -
Evaluating the Cologuard Test for Use in Lynch Syndrome
|
||
| Withdrawn |
NCT01372696 -
Endoscopic Characteristics of Colonic Tumours
|
N/A | |
| Recruiting |
NCT05322993 -
Improving Polyp Detection Rate by Artificial Intelligence in Colonoscopy
|
N/A | |
| Completed |
NCT03121495 -
Study on Second Forward View Examination in the Right Colon
|
N/A | |
| Completed |
NCT03344055 -
Endocuff-assisted Colonoscopy vs Standard Colonoscopy on Adenoma Detection Rate
|
N/A | |
| Recruiting |
NCT06063720 -
Effective Withdrawal Time and Adenoma Detection Rate
|
||
| Completed |
NCT06426745 -
Split-dose Versus Single-dose Bowel Preparation for Colonoscopy
|
N/A | |
| Recruiting |
NCT04220905 -
Endoscopic Resection of Large Colorectal Polyps: An Observational Cohort Study
|