Colonic Neoplasms Clinical Trial
Official title:
A Prospective Study Assessing Whether Immunoscore Colon Test Impacts the Choice of Adjuvant Chemotherapy, in a Multidisciplinary Meeting, for Treating Non-metastatic Colon Cancer Patients After Curative-intent Surgery
Immunoscore Colon Test (ICT) will be applied on tumor samples from curative surgery. In the Multidisciplinary Meeting (MM) evaluating the participant adjuvant strategy, a first decision will be taken, based on the participant medical record only. ICT will then be disclosed and the MM will take a second decision. The aim of the study is to observe if the ICT result modifies the treatment decision.
On previous studies, Immunoscore Colon test identified subgroups of stage II and III colon
cancer patients whose Chemotherapy could be adjusted.
The study hypothesis is that Immunoscore Colon Test will modify the therapeutic decision in
MM.
With Alpha and Beta at 5% and p0=10% modification rate, the participating investigators need
to include 280 participants, 140 in each cohort (stage II and stage III).
Participants will have tumor samples from their curative surgery tested with Immunoscore
Colon. When the patients are evaluated in MM, a first therapeutic decision will be taken
before disclosing the test result. ICT result will then be communicated and a second decision
will be taken.
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