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Strigolactones and Dysplastic Colonic Lesions or Cancer

Colonic Neoplasms Clinical Trial

Official title:
The Effect of the Plant Hormones Strigolactones on Cultures of Dysplastic Colonic Lesions and Cancer

Clinical Trial Summary

The purpose of this study is to determine the effects of the plant hormones strigolactones, on cell cultures of colonic polyps and colorectal cancer.

Clinical Trial Description

Strigolactones have been shown to anti-proliferative and pro-apoptotic effects in cell cultures of breast and prostate origin, partially by down-regulation of cyclin B1 and induction of cell cycle arrest. In this study the investigators intend to take biopsies from benign colonic polyps and cancer tissue, culture intestinal explants and generate immortalized primary cells as a platform to assess the effect of this plant hormone on cell viability, cell mobility, apoptosis and cytoskeleton modifications. ;

Study Design

Observational Model: Case-Only, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02824835
Study type Observational
Source Meir Medical Center
Contact Ido Laish, MD
Phone + 972-9-7473261
Email ido.lish@clalit.org.il
Status Not yet recruiting
Phase N/A
Start date July 2016
Completion date December 2017
View Details
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