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Imatinib as Pre-operative Anti-Colon Cancer Targeted Therapy — ImPACCT  

Colonic Neoplasms Clinical Trial

Official title:
Targeted Therapy With Imatinib for Treatment of Poor Prognosis Mesenchymal-type Resectable Colon Cancer: a Proof-of-concept Study in the Preoperative Window Period.

Clinical Trial Summary

In this proof-of-concept trial the investigators will study the effects of imatinib treatment on the biology of mesenchymal-type colon cancers.

Clinical Trial Description

Tumor biopsies from patients with newly diagnosed colon cancer will be pre-screened with an RT-qPCR test to identify tumors of the mesenchymal subtype. Patients with mesenchymal-type tumors that meet the in- and exclusion criteria will be treated with imatinib during the "window period" that normally precedes surgery. Immediately following tumor resection, biopsies will be taken from the surgical specimen. Gene and protein expression of the pre- and post-treatments biopsies will be compared to assess the effects of imatinib therapy on PDGFR- and cKIT-signalling and on the mesenchymal gene expression profile. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02685046
Study type Interventional
Source UMC Utrecht
Contact
Status Terminated
Phase Phase 2
Start date April 2016
Completion date September 1, 2019
View Details
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