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NCT04185272 Clinical Trial

Butyrophilins Role in Colon Cancer

Colonic Cancer Clinical Trial

Official title:
Role of Butyrophilins in Colon Cancers Aggressiveness Evaluation

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT04185272
Other study ID # IMMUNOCOL-IPC 2019-018
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date June 30, 2020
Est. completion date June 2028

Study information
Verified date April 2022
Source Institut Paoli-Calmettes
Contact Dominique Genre, Dr
Phone 04 91 22 37 78
Email drci.up@ipc.unicancer.fr
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

quantification of BTNL molecules in colon cancer in order to determinate if their could be used as a prognostic marquer

Recruitment information / eligibility
Status Recruiting
Enrollment 200
Est. completion date June 2028
Est. primary completion date June 2023
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Patient is older than 18 years old, - Signed participation consent, - Non-metastatic colon cancer immediately resectable or metastatic and liver synchronous for which it was decided a combined colic and liver surgery (metastatic patient at the outset) in multidisciplinary consultation meeting. - Performance Status (PS) 0 or 1 - affiliated to the social security or beneficiary Exclusion Criteria: - Rectal cancer, colon cancer recurrence - Emergency of colon cancer Surgery - History of inflammatory disease of the digestive tract (Crohn's disease or ulcerative colitis) - Patient who received neoadjuvant therapy other than chemotherapy - Patient treated with immune-suppressors or long-course corticosteroids <12 months - Pregnant women or likely to be pregnant (without effective contraception) or breastfeeding, - Person in urgent situation, person under legal protection measure, or unable to express his / her consent, - Impossibility of submitting to the medical examination of the test for geographical, social or psychological reasons

Study Design

Related Conditions & MeSH terms

Intervention

Biological:
• analysis of BTN and BTNL status
analysis of BTN and BTNL expression in colon cancer and hepatic metastasis

Locations
Country Name City State
France Lopez Almeida Marseille

Sponsors (1)
Lead Sponsor Collaborator
Institut Paoli-Calmettes

Country where clinical trial is conducted

France, 

Outcome
Type Measure Description Time frame Safety issue
Primary evaluation of BTNL3, BTNL8 and BTNL9 expression by transcriptomics and immunohistochemistry healthy and cancerous colon ad metastasis (if applicable) will be analysed by 8 years
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