To Determine the Efficacy and Safety of Envafolimab Combined With XELOX for Locally Advanced Colon Cancer

Colon Cancer Clinical Trial

Official title:

Envafolimab Combined With XELOX in Neoadjuvant Therapy for Locally Advanced Colon Cancer，A Prospective, Single Arm, Single Center ǁ Phase Clinical Trial

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT05335460
• Other study ID #: STEP-EX001
• Status: Not yet recruiting
• Phase: Phase 2
• Start date: May 2022
• Est. completion date: May 2024

Study information

• Verified date: April 2022
• Source: Fujian Cancer Hospital
• Contact: Zaisheng Ye
• Phone: 13950203076
• Email: flyingengel[@]sina.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The objective is to investigate the efficacy and safety of Envafolimab combined with XELOX in neoadjuvant therapy for locally advanced colon cancer

Description:

According to the 2019 NCCN guidelines, immunocheckpoint inhibitors are recommended for first-line treatment of metastatic colon cancer patients with high microsatellite instability (msi-h) or mismatched gene deletion (dMMR) who are not suitable for intensive treatment, and for all patients with second-line or above msi-h /dMMR treatment.

This study is a single-center, single-arm phase II study, patients received neoadjuvant therapy with Envafolimab combined with XELOX regimen, with one treatment cycle every 3 weeks and after two cycles accept surgery. To determine the pathologic downstage rates at time of radical resection of colon cancer following neoadjuvant treatment.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 36
• Est. completion date: May 2024
• Est. primary completion date: May 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria:

1. Histological confirmation of colon adenocarcinoma

2. Radiological signs, evaluated by CT, of T4 or Tany N+ (AJCC 8th) 3 No metastatic involvement in other organs (M0). 4 Uncomplicated primary tumor 5 Patients who have not received systemic chemotherapy or other anti-tumor treatment 6 18-75 years; 7 ECOG 0-1; 8 The patient must have adequate organ function and meet the following laboratory test values during the screening period within 7 days before enrolling:

• Absolute neutrophil cell count (ANC) =1.5x109/L, platelet =75x109/L, hemoglobin =90g/L.(in (Patients with no blood transfusion or growth factor support should be given for 7 days prior to blood collection.)

• Serum creatinine =1.5× upper normal range (ULN) or estimated creatinine clearance =50mL/min, Glutamate aminotransferase and glutamate aminotransferase (AST and ALT)=3×ULN.

• Total bilirubin =1.5×ULN;If there is Gilbert syndrome or if the indirect bilirubin concentration indicates an extrahepatic source of bile The rise of erythrosin is =3×ULN.

• Aptt =1.5×ULN, and INR or PT=1.5×ULN. 9 Systemic corticosteroids or other systemic immunosuppressive drugs were used within 2 weeks prior to treatment. Immunosuppressive drugs were started or expected to be used during the trial. Inhaled corticosteroids, physiologic replacement doses of glucocorticoids are allowed 10 Sign written informed consent. 11 Expected overall survival =3 months 12 A person is operation and compliance with medical treatment

Exclusion Criteria:

1. Known to be allergic to any study drug

2. The patient has a history of autoimmune disease

3. Systemic corticosteroids or other systemic immunosuppressive drugs were used within 2 weeks prior to treatment.

4. The patient has severe active infections

5. A person is known to be infected with the immunodeficiency virus (HIV) or known to be HIV-positive 6?Patients Have high blood pressure that cannot be well controlled by antihypertensive medication or any other uncontrolled disease

7 pregnant women or Lactating women 8 The patient has mental illness and cannot comply with the study regulations 9 According to the judgment of the researcher, the patient have other factors that may affect the results of the study or cause the study to be terminated, such as alcohol abuse, drug abuse, other serious diseases (including mental diseases) requiring combined treatment. Patients have severe laboratory abnormalities, which will affect the safety of the patient.

Related Conditions & MeSH terms

• Colon Cancer
• Colonic Neoplasms

Intervention

Drug:
• Envafolimab
300mg,sc,d1,Q3W

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Fujian Cancer Hospital

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	PCR rate	There were no residual tumor cells under microscope	within 7 days after surgery
Primary	TRG0/1	the rate of Tumor Regression Grading level 0/1	within 7 days after surgery
Secondary	R0 resection rate	The tumor was completely removed, and the cutting edge was negative under microscope, without tumor residue	within 7 days after surgery
Secondary	ORR	Objective response rate	within 1 year after surgery