A Study of Niclosamide in Patients With Resectable Colon Cancer

Status Terminated

Clinical Trial Summary

This study evaluates the safety of Niclosamide in patients with colon cancer that are undergoing primary resection of their tumor. This is a phase I study with three dosage levels to determine the maximum tolerated dose (MTD).

Clinical Trial Description

Niclosamide is a drug traditionally used in parasitic infections that has recently been shown to regulated the Wnt signaling pathway in cells at the level of the Frizzled receptor.

The Wnt pathway is critical for embryogenesis, differentiation of progenitor cells, and supports proliferation of neoplastic tissue. In cancer, activation of the Wnt pathway leads to increased transcription of genes important for growth, proliferation, differentiation, apoptosis, genetic stability, migration, and angiogenesis. The Wnt pathway has particular importance in colorectal cancer.

The purpose of this study is to obtain safety data along with pharmacokinetic data and information on the changes in the WNT pathway signalling following niclosamide administration in humans. This phase I study will support future studies in patients with more advanced cancer and other cancers with dysregulation of the Wnt pathway. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02687009
Study type	Interventional
Source	Duke University
Contact
Status	Terminated
Phase	Phase 1
Start date	November 7, 2017
Completion date	December 12, 2017

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