Colo-rectal Cancer Clinical Trial
Official title:
Computed Tomography Perfusion of Colorectal Cancer in Correlation With Tumor Grade
Colorectal cancer is the third most commonly diagnosed cancer in the world. The 5-years survival rate depends on the tumor stage and grade at patient presentation. Individual treatment strategy based on the tumor stage and grade should be applied to improve the prognosis, So the pre-operative diagnostic evaluation and grading of colorectal cancer are important.
Status | Not yet recruiting |
Enrollment | 50 |
Est. completion date | July 10, 2019 |
Est. primary completion date | March 10, 2019 |
Accepts healthy volunteers | No |
Gender | All |
Age group | N/A and older |
Eligibility |
Inclusion Criteria: - Any patient with primary colorectal mass Exclusion Criteria: - Colorectal mass pathologically proved to be benign Female patient at child bearing period with suspected pregnancy Raised renal chemistry Hypersensitivity to contrast. |
Country | Name | City | State |
---|---|---|---|
Egypt | Faculty of Medicine | Assiut |
Lead Sponsor | Collaborator |
---|---|
Assiut University |
Egypt,
Dighe S, Castellano E, Blake H, Jeyadevan N, Koh MU, Orten M, Swift I, Brown G. Perfusion CT to assess angiogenesis in colon cancer: technical limitations and practical challenges. Br J Radiol. 2012 Oct;85(1018):e814-25. doi: 10.1259/bjr/19855447. Epub 2012 Apr 18. — View Citation
Goh V, Glynne-Jones R. Perfusion CT imaging of colorectal cancer. Br J Radiol. 2014 Feb;87(1034):20130811. doi: 10.1259/bjr.20130811. Review. — View Citation
Kim JW, Jeong YY, Chang NK, Heo SH, Shin SS, Lee JH, Hur YH, Kang HK. Perfusion CT in colorectal cancer: comparison of perfusion parameters with tumor grade and microvessel density. Korean J Radiol. 2012 Jan-Feb;13 Suppl 1:S89-97. doi: 10.3348/kjr.2012.13.S1.S89. Epub 2012 Apr 23. Erratum in: Korean J Radiol. 2012 Jul-Aug;13(4):522. — View Citation
Marley AR, Nan H. Epidemiology of colorectal cancer. Int J Mol Epidemiol Genet. 2016 Sep 30;7(3):105-114. eCollection 2016. Review. — View Citation
Sun H, Xu Y, Yang Q, Wang W. Assessment of tumor grade and angiogenesis in colorectal cancer: whole-volume perfusion CT. Acad Radiol. 2014 Jun;21(6):750-7. doi: 10.1016/j.acra.2014.02.011. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Blood flow of tumor | Accuracy of blood flow of the tumor in prediction of tumor grade in correlation with histopathological results | One month | |
Secondary | Blood volume of the tumor | Accuracy of blood volume of the tumor in prediction of tumor grade in correlation with histopathological results | One month | |
Secondary | Mean transient time of the tumor | transient time of the tumor in prediction of tumor grade in correlation with histopathological results | One month | |
Secondary | Permeability surface of the tumor | Accuracy of permeability surface of the tumor in prediction of tumor grade in correlation with histopathological results | One month |
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