Colo-rectal Cancer Clinical Trial
Official title:
Investigating the Role of SPG20,STK31 Genes in the Carcinogenesis of Colorectal Cancer
Colo rectal cancer is one of the greatest ,mutual malignancies worldwide ,accounting for an estimated 1.3 million new cases and >500,000 mortality ⁄ year . is the fourth leading cause of cancer-associated mortality worldwide with speedily ,cumulative ,occurrence rate in the worldwide
colo rectal cancer represents a global and local problem, as it is one of the commonest types
of cancer all over the world. Globally, Colo rectal cancer in women (9.2% of diagnoses) it is
the second most common cause of cancer . it is the third most common in men (10.0%). After
lung, stomach, and liver cancer it is the fourth most common cause of cancer death.
Cancer is a multistep procedure resulting from an ongoing accretion of genetic and epigenetic
fluctuations to the genome.
Spartin is a protein that in humans is encoded by the SPG20 gene. This protein may be
involved in endosomal trafficking, microtubule dynamics, or both functions. Aberrant promoter
methylation of genes is a common epigenetic alteration in colo rectal cancer .
This has stimulated the prospect to implement a dependable, reasonable and simple approach
for Colo rectal detection . The SPG20 gene is situated in chromosome band 13q13.3; the SPG20
gene converts the spartin protein, which is a multi functional protein that has formerly been
recognized to be complicated in intra cellular epidermal growth factor receptor trading , The
serine-threonine kinase 31 (STK31) gene was initially identified through cDNA subtraction as
a testis-specific protein kinase gene expressed in mouse spermatogonia . Recently, STK31 has
been described as a novel cancer testis (CT) antigen, highly expressed in Gastrointestinal
cancer cells (colo rectal, gastric and esophageal cancer), while restricted to testis and
fetal brain in normal tissues .
It was found that SPG20 is mutated in Troy er syndrome, an hereditary spastic paraplegia
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