Cognitive Impairment Clinical Trial
Official title:
Cognitive Training to Prevent Postoperative Cognitive Dysfunction in Older Patients - A Randomised Controlled Trial
Postoperative Cognitive Dysfunction (POCD) is a state of decline in cognitive ability after surgery and is frequently seen among our elderly population. Many studies have looked into predictive risk factors for POCD while research is underway to search for pre-emptive measures to avoid this unfavourable outcome. Most will be looking at utilizing mobile software applications of cognitive training but in many poorer countries, owning electronic devices may not be an option or may be culturally less acceptable among the older patients. Hence, the investigators intend to investigate if a home-based logbook for cognitive training will reduce the incidence of POCD in a single centre study.
Background:
Postoperative Cognitive Dysfunction (POCD) is a state in which a decline in cognitive ability
after surgery persist from early postoperative period to a much longer term. It is said to be
a subtle disorder of thought processes that influences domains of cognition such as memory
especially short-term memory, inattention and inability to focus with the presence of
generalized slowness. In fact, a lot of older patients and their loved ones claim they are
'never the same' after the surgery. It is to be distinguished from postoperative delirium, a
diagnosis portrayed through several symptoms that occurs acutely after surgery, fluctuates
with time and has a tendency to be transient. POCD, on the other hand, is difficult to
diagnose and only detected by comparing postoperative results of neuropsychological battery
tests to those done as baseline preoperatively.
Advanced age is a major risk for developing POCD.6 Studies done by the International Study of
Postoperative Cognitive Dysfunction (ISPOCD) group had found an incidence of POCD at 19.2%
within 1 week and 6.2% in 3 months. Similar studies have reported a higher figure of 36.1% at
1 week after surgery for this phenomenon. In certain high-risk groups, the range ascends to
16 - 62% with an average of 35% in hip fracture patients9 and up to 60% for those who
underwent cardiac surgery that persist in 10-30% after 6 months.
Hypothesis:
As far as research is concerned, tremendous efforts are now underway to look for causes of
POCD and its risk factors but most importantly, find ways to avoid this disability over time.
Clinicians instinctively prescribe prehabilitation in preparation for surgery through various
physical conditioning to improve patients' physiological cardio-respiratory reserve in the
hope for better recovery. The investigators hypothesize that the same holds true with
cognitive function and by optimizing mental 'fitness', the pre-conditioning can attribute to
a decrease in POCD.
Currently, there are a few ongoing trials such as NeuroBics in US15 for non-cardiac surgery
and Cog-train in UK for cardiac patients investigating the role of using electronic-based
'brain' intervention before surgery. The investigators aim to test the feasibility of using a
home based logbook with easy applicability as the cognitive training to produce equally
favourable results in reducing POCD since the socio-economic pattern of our older population
is different from the west. Senior citizens may not be familiar with or have difficulty to
afford electronic devices and are less engaged with web-based Internet as reflected by data
from a local service provider that found only 3.9% of their user base in the country is over
the age of 60.
Sample size:
Based on 36% POCD at one week from a previous study8 and our proposed 50% reduction to 18%
incidence with intervention, a total of 232 participants (including 10% drop-out rate) are
required at a 1:1 ratio between groups to achieve an 80% powered study and Type 1 error of
5%.
A preliminary analysis will be done at 50 recruited patients to look for feasibility of
continuing this study.
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