Cognitive Impairment Clinical Trial
— ISAACOfficial title:
Insulin Like Growth Factor 1 and Risks of Sarcopenia and Mortality in Patients With Cognitive Impairment
Verified date | September 2013 |
Source | University of Roma La Sapienza |
Contact | n/a |
Is FDA regulated | No |
Health authority | Italy: Istituto Superiore di Sanità |
Study type | Observational |
Insulin-like growth factor 1 (IGF)-1 is an important neuromyotrophic hormone. Disregulation of this hormone has been reported to influence the genesis of cognitive impairment and dementia in the elderly patients. We analyzed the possible link between IGF-1 and risk of Sarcopenia and Mortality in a cohort of elder patients with cognitive impairment.
Status | Completed |
Enrollment | 589 |
Est. completion date | November 2013 |
Est. primary completion date | September 2013 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 65 Years to 90 Years |
Eligibility |
Inclusion Criteria: - Diagnosis of cognitive impairment (MMSE < 24) - Age > 65 ys Exclusion Criteria: - Diagnosis of pancreatic disorders - Diagnosis of acromegaly - Diagnosis of GH-related disorders - Recent bone fractures or immobility before the enrollment (3 months) - Cancer |
Observational Model: Cohort, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
Italy | IRCCS Galeazzi | Milan | |
Italy | Sapienza University of Rome | Rome |
Lead Sponsor | Collaborator |
---|---|
University of Roma La Sapienza |
Italy,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | IGF-1 reduction in patients with sarcopenia | IGF-1 reduction could be linked to sarcopenia in patients with cognitive impairment | baseline, 24 months, 48 months | No |
Secondary | IGF-1 reduction and mortality in patients with cognitive impairment | IGF-1 could be an independent risk factor for mortality in patients with cognitive impairment | baseline, 24 months, 48 months | No |
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