MOBility Disorders Assessment in Patients With Mild COGnitive Disorders — COG-MOB  

Cognitive Dysfunction Clinical Trial

Official title: Multimodal and Longitudinal Assessment of MOBility Disorders in Patients With Mild COGnitive Disorders

Status Recruiting

Clinical Trial Summary

Mild cognitive impairment (MCI) is defined by lower performance in one or more cognitive domains with preservation of independence in functional abilities. Sixteen percent of community-dwelling older people (over 65 years) live with MCI. They are both cognitively and physically vulnerable. From a cognitive perspective, they are susceptible to converting to the dementia stage at an annual rate of 10%. From a physical perspective, the proportion of slow gait or neurological gait abnormalities can reach 46% in the population with MCI. Falls in turn increase the risk of accelerated cognitive decline and the risk of institutionalization. In the absence of a curative treatment for dementia, it is essential to have an effective and personalized prevention strategy by identifying the predictive factors for falls in this at-risk population with MCI.

The research goals of this project are 1) to identify specific predictors for falls in clinic attendees with MCI in preparation for a definitive, fully powered study across France, and 2) to demonstrate the feasibility of a pragmatic fall risk assessment in MCs, whatever its setting and location.

We aim to prospectively follow-up people diagnosed with MCI and aged above 65 years old in four MCs in France (three in the North (one community-based MC), and one in the Centre) for one year.

Clinical Trial Description

n/a

Related Conditions & MeSH terms

• Cognition Disorders
• Cognitive Dysfunction

• NCT number: NCT05273125
• Study type: Observational
• Source: University Hospital, Lille
• Contact: Yaohua CHEN, MD
• Phone: 0320445962
• Email: Yaohua.chen@chru-lille.fr
• Status: Recruiting
• Start date: September 9, 2022
• Completion date: September 2025