Cognitive Dysfunction Clinical Trial
Official title:
Multiple Interventions to Prevent Cognitive Decline
The investigators aim to test the feasibility of a pragmatic non-pharmacological strategy,
that may prevent cognitive decline in patients with mild cognitive impairment. This strategy
is based on five different interventions: cognitive training, physical activity, nutrition
education, adaption to memory loss, diagnosis and correction of hearing impairment.
A quasi-experimental study will be implemented in Porto (Portugal), including patients that
fulfill all of the following criteria: a) age 18-85 years; b) Montreal Cognitive Assessment
(MoCA) score greater than or equal to two standard deviations below the normative reference
value for the corresponding age and education level in the Portuguese population OR diagnosis
of Mild Cognitive Impairment, performed by a Neurologist, during the six previous months,
considering the results of a neuropsychological battery; c) Cardiovascular Risk Factors,
Aging and Dementia (CAIDE) Dementia Risk Score of at least six points. Patients who have any
medical disability that contraindicates physical activity or have a lack of autonomy in daily
activities will be excluded.
The program will be implemented in groups of 10 participants, over a period of 10 consecutive
months.
Detailed description
This is a quasi-experimental study in which the investigators aim to test the feasibility of
a non-pharmacological strategy to prevent cognitive decline in patients with a diagnosis of
mild cognitive impairment. This strategy is based on five different interventions:
a) Cognitive training
This comprises training using using the cogweb software, both in person and remotely:
i) in person training: 30-minute sessions, supervised by a trained nurse, twice weekly .
ii) remote training: unsupervised 30-minute sessions, to be performed at home at the
participants will.
b) Physical activity This is based on 60-minute sessions including aerobic, resistance,
agility/balance and flexibility exercises, directed by a physical education teacher and
supervised by a nurse, twice weekly.
c) Nutrition education
This is based on monthly 180-minute sessions, directed by a nutritionist, comprising:
i) Presentation and discussion of healthy and easy to cook recipes by the nutritionist; ii)
Preparation of healthy meals by the participants, followed by a period of social interaction
between the participants while consuming the meals prepared.
d) Adaptation to memory loss This is based on monthly 30-minute sessions, directed by a
psychologist or a nurse, who will provide strategies that participants may use in their daily
life to cope with memory loss.
e) Diagnosis of hearing impairment Before implementing the sessions of cognitive training,
physical activity, nutrition education and adaption to memory loss, an audiologist will
perform an audiogram to all participants. Those with auditive performance inferior to the
reference values will be referred for a medical appointment with an otolaryngologist.
Strategies (a),(b), (c) and (d) will be implemented over a period of 10 months, in groups of
10 participants.
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