Cognitive Dysfunction Clinical Trial
Official title:
The Effect of Dexmedetomidine and Esmolol on Early Post Operative Cognitive Dysfunction After Middle Ear Surgery Under Hypotensive Technique :Comparative , Randomized Double Blinded Study
Dexmedetomidine is a highly selective α2adrenoceptor agonist recently introduced to
anesthesia that produces dose dependent sedation, anxiolysis, and analgesia (involving spinal
and supraspinal sites) without respiratory depression.
From a pharmacokinetic perspective,dexmedetomidine has a half life of nearly 2 hours,
duration of action of nearly 4 hour, and thus, a side effect profile that is shorter in
duration than clonidine.
Esmolol is a cardioselective beta₁ receptor blocker with rapid onset, a very short duration
of action (elimination half-life is approximately 9 minutes) , and no significant intrinsic
sympathomimetic or membrane stabilising activity at therapeutic dosages
The study will be a randomized double blinded study and will be carried by the Department of Anaesthesia at Beni-Suef University Hospital after obtaining approval from local research and ethical committee. Written informed consent will be obtained from each patient before operation. Aiming to assess of the early cognitive dysfunction after controlled hypotensive anesthesia with either dexmedetomidine or esmolol during middle ear surgeries ;
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