Cognitive Dysfunction Clinical Trial
Official title:
Near Infrared Spectroscopy for Detection of Cerebral Desaturation After Positioning for Neurosurgical Procedure
Verified date | September 2019 |
Source | University Hospital Hradec Kralove |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The occurrence of postoperative cognitive dysfunction (POCD) might be related to intraoperative cerebral desaturation. Positioning for neurosurgical procedures are associated with head rotation, elevation, flexion or extention that may affect blood brain inflow and outflow. Anatomical variations of Willis circle could affect the cerebral blood flow in extreme head position with the development of cerebral ischemia or functional changes of brain. Investigators suppose that detection of cerebral tissue desaturation and its prompt correction could modify the occurence of POCD after these procedures.
Status | Completed |
Enrollment | 100 |
Est. completion date | June 30, 2019 |
Est. primary completion date | December 31, 2018 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 75 Years |
Eligibility |
Inclusion Criteria: - Glasgow Coma Scale 15, American Society of Anaesthesiologists (ASA) Physical Status Classification System Grade I-III, patient positioning with elevation, rotation, flexion or extention of head Exclusion Criteria: - Inability to past the Addenbrooke test, postoperative ventilation, awake phase during surgery, lung disease with retention of carbon dioxide, neurological disease before surgery (aphasia, paresis, blindness, deafness) |
Country | Name | City | State |
---|---|---|---|
Czechia | University Hospital Hradec Kralove | Hradec Kralove |
Lead Sponsor | Collaborator |
---|---|
University Hospital Hradec Kralove |
Czechia,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Reduction of incidence of postoperative cognitive dysfunction (POCD) | Addenbrooke test | 1 day before operation and the fifth´day | |
Secondary | Operative position of patient | In grades from neutral position | first 30 minutes | |
Secondary | Age of patients | 18 to 79 | the first 5 minutes | |
Secondary | Level of exhaled carbon dioxide | In torr | every 5 minutes | |
Secondary | Type and duration of procedure | In minutes | 10 minutes after procedure | |
Secondary | Dose of catecholamines | In microgramms per kg per minute | 5 minutes after procedure |
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