Pharmacogenetic Study for Topiramate-Induced Cognitive Dysfunction

Status Recruiting

Clinical Trial Summary

Topiramate (TPM) is an antiepileptic drug with a unique mode of action that is often useful in patients refractory to other drugs. However its use is restricted by the high incidence of cognitive adverse drug reactions (ADRs) that are associated with TPM exposure. TPM has been shown to cause particular cognitive ADRs, characterized by verbal fluency, attention, working memory and language deficits, at a much higher rate than other antiepileptic drugs. There do not appear to be obvious differences between patients that do or do not experience cognitive ADRs when on TPM (e.g. age, sex, concomitant medications, diagnosis), which suggests a genetic contributor.

Clinical Trial Description

n/a

Study Design

Observational Model: Case-Only, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00731900
Study type	Observational
Source	National Taiwan University Hospital
Contact	Horng-Huei Liou, MD;PhD
Phone	886-2-23123456
Email	hhl@ntu.edu.tw
Status	Recruiting
Phase	N/A
Start date	April 2007
Completion date	December 2009

View Details

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