Cognitive Deficits Clinical Trial
Official title:
Amyloïd Load in Elderly Population: Effect of Cognitive Reserve
This research aim to explore relationships between the presence of amyloid burden and cognitive performance, and its modulation by educational level. For this purpose we will combine Positron emission tomography (PET) imaging and neuropsychological assessment acquired on 3 groups of subjects, from two population-based cohorts "3C" and "AMIMage" The first group includes cognitively intact participants who will serve as controls, the second group, subjects with mild cognitive impairments without memory complaint and the third, subjects with both mild cognitive impairments and memory complaint.
Influence of educational level on the relationship between disease-specific lesion
development and cognitive function will be assessed, as measured by amyloid PET imaging and
a battery of neuropsychological tests at the very early stages of the disease, comparatively
to age-matched controls. In addition, this project will explore the influence of cognitive
complaint.
It's assumed that 1) the amyloid-PET measures in age-matched controls and subjects from the
two cohorts will correlate with cognitive performances; 2) the amyloid burden will be higher
in high- than in low-educated subjects with similar cognitive impairment; and 3) similarly
the amyloid burden will be higher in subjects with cognitive complaint compared to subjects
without cognitive complaint.
Considering a longer term, the clinical follow-up of study participants will allow to
investigate the prognosis value of amyloid load for improving the prediction of cognitive
decline and disease progression.
;
Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Terminated |
NCT02266121 -
Improving Cognitive Aptitudes With tDCS in Patients With Multiple Sclerosis
|
N/A | |
| Not yet recruiting |
NCT02122042 -
Hyperbaric Oxygen Therapy Can Improve Cognitive Deficits Post Low Grade Glioma Removal Surgery
|
Phase 1 | |
| Terminated |
NCT02746523 -
Effects of Multiple Concussions in Retired NHL Players
|
N/A | |
| Completed |
NCT01359215 -
Childhood Anesthesia and Cognitive Function
|
N/A | |
| Terminated |
NCT01813955 -
Phosphodiesterase (PDE) Inhibitors Effect on Cognitive Deficits Associated to Schizophrenia
|
Phase 0 | |
| Completed |
NCT02816008 -
Smart Autonomous Neuro-Rehabilitation System
|
N/A | |
| Completed |
NCT01889602 -
Characterizing and Predicting Drug Effects on Cognition
|
Phase 4 | |
| Completed |
NCT02393079 -
Analysis of TCLT in TBI Patients: a Prospective, Randomized Controlled Trial
|
N/A | |
| Completed |
NCT01763983 -
Effects of Cognitive Behavioural Therapy and Exercise on Stress and Cognitive Deficits in Multiple Sclerosis
|
N/A | |
| Completed |
NCT01302314 -
Cognitive Rehabilitation in Patients With Spina Bifida
|
N/A | |
| Withdrawn |
NCT04064021 -
Acupuncture Treatment for Improving Alzheimer's Dementia
|
N/A | |
| Completed |
NCT02505477 -
Treatment of Cognitive and Negative Symptoms in Schizophrenia With N-acetylcysteine
|
Phase 4 | |
| Completed |
NCT03017560 -
Treating Verbal Memory Deficits Following Chemotherapy for Breast Cancer
|
N/A | |
| Completed |
NCT02360813 -
Cognitive Remediation Therapy Within a Secure Forensic Setting
|
N/A | |
| Not yet recruiting |
NCT02178995 -
Methylphenidate Treatment of Attention Deficits in Epilepsy
|
Phase 4 | |
| Active, not recruiting |
NCT02141022 -
Computerized Exercise Training for Cognitive Remediation in Adults With Multiple Sclerosis Treated With Gilenya
|
N/A | |
| Completed |
NCT00974376 -
Gabapentin Treatment of Cannabis Dependence
|
Phase 2 | |
| Completed |
NCT03623477 -
Can Cognitive Training Decrease Reactive Aggression?
|
N/A | |
| Completed |
NCT03621540 -
Augmentation of Working Memory Training With Transcranial Direct Current Stimulation in Patients With Schizophrenia
|
N/A | |
| Completed |
NCT02847793 -
Attentional Bias Modification Through Eye-tracker Methodology (ABMET)
|
N/A |