Clinical Trials Logo

Clinical Trial Summary

The objectives of this study are to: (1) determine the effects of combinatorial training (i.e. combinatory of aerobic exercise with cognitive training and guiding training) vs. the sequential training (i.e. a combination of aerobatic exercise with cognitive training) on cognitive function, physical function, and daily function/participation and psychological function in persons with cognitive impairments post Traumatic brain injury (TBI); (2) determine the long-term effects of these two types of interventions on these outcome measures.


Clinical Trial Description

Cognitive deficits and dysfunction in daily participation are common in patients with traumatic brain injury. Previous studies have reported positive effects on cognitive function after computerized cognitive training, aerobic exercise, or a combination of the two, however, the effects are variable and hardly be transferred to enhance daily participation. It is thus still inconclusive that which types of interventions are better for cognitive remediation and daily participation in patients post traumatic brain injury. Several pioneering studies used guided training for patients with brain injury to acquire problem-solving skills, improve life function and promote participation. After the training, the effect lasted for six months. However, due to insufficient research samples, it was inferior in generalizability. In the present project, the investigators design an innovative combinatorial training that composites of guided training, computerized cognitive training, and aerobic exercise. The investigators expected that this combinatorial training not only improve cognitive ability but also facilitate daily participation in patients with traumatic brain injury. The investigators plan to recruit 50 patients with traumatic brain injury who have cognitive deficits and will assign them randomly into two groups: sequential training group, and combinatorial training group. There will compare the immediate effects and long-term effects of combinatorial training and combined training (computerized cognitive training plus aerobic exercise) on cognitive function and daily function/participation and psychological function of persons with traumatic brain injury. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04051528
Study type Interventional
Source Chang Gung Memorial Hospital
Contact Ching-yi Wu, ScD
Phone #886-3-2118800
Email cywu@mail.cgu.edu.tw
Status Recruiting
Phase N/A
Start date June 3, 2020
Completion date January 2022

See also
  Status Clinical Trial Phase
Active, not recruiting NCT04961112 - Evaluating the Efficacy of Cranial Electrotherapy Stimulation in Mitigating Anxiety-induced Cognitive Deficits N/A
Completed NCT03695614 - Cognitive Remediation Therapy for Participants With Late-Life Schizophrenia N/A
Active, not recruiting NCT05879562 - Validation of a Digital Self-Administered Cognitive Screening Tool: MoCA-XpressO N/A
Completed NCT03286439 - Recovery After Medical or Surgical Treatment
Recruiting NCT04251624 - Investigating the Use of Goal Management Therapy in Improving Cognitive Functioning in Public Safety Personnel With PTSD N/A
Not yet recruiting NCT02763397 - Deep Brain Stimulation (DBS) of the Nucleus Basalis of Meynert (NbM) in Patients With Parkinson's Disease N/A
Recruiting NCT03036319 - Patient-Centered NeuroRehabilitation (PCN) N/A
Recruiting NCT05251454 - Studying the Effects of Brain Stimulation on Cognitive Control and Associated EEG in Human Subjects. N/A
Completed NCT05063669 - Cognitive Intervention in Attention Deficit and Hyperactivity Disorder N/A
Completed NCT02964221 - Cognitive Changes After Major Joint Replacement N/A
Not yet recruiting NCT05605366 - Minocycline In Neurocognitive Outcomes - Sickle Cell Disease Phase 1
Completed NCT02214342 - Virtual Reality Based Balance Training in People With Mild Cognitive Impairment N/A
Terminated NCT03032471 - Swiss SOS MoCA - DCI Study
Recruiting NCT04456777 - Effect of Vortioxetine on Cognitive Symptoms in Patients With Schizophrenia Early Phase 1
Recruiting NCT04204239 - Validation Study SCOBES-AR
Withdrawn NCT04457271 - Goal Management Training in Individuals With PTSD N/A
Terminated NCT03034109 - Transcranial Direct Current Stimulation (tDCS) in Post-Stroke Working Memory Deficits N/A
Recruiting NCT05802680 - Neurocognitive Effects of Non-Invasive Near-Infrared Light Stimulation N/A
Active, not recruiting NCT02847403 - Long-acting Exenatide and Cognitive Decline in Dysglycemic Patients Phase 3
Withdrawn NCT04654130 - Neurofeedback Effectiveness Trial in PTSD N/A