Oxygen as a Limiting Factor for Performing Multitasking

Cognitive Change Clinical Trial

Official title:

Oxygen as a Limiting Factor for Performing Multitasking: Functional Evaluation Under Normobaric and Hyperbaric Oxygenation of Healthy Participants

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03126669
• Other study ID #: 213/13
• Status: Completed
• Phase: N/A
• First received: April 20, 2017
• Last updated: January 15, 2018
• Start date: November 1, 2014
• Est. completion date: March 25, 2017

Study information

• Verified date: April 2017
• Source: Assaf-Harofeh Medical Center
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The Brain uses 20% of the total oxygen supply consumed by the entire body. Even though, less than 10% of the brain is active at every given time, the brain utilizes almost all the oxygen delivered. In order to perform different tasks or more than one task (multi-tasking), the oxygen supply is shifted from one brain region to another, via modulation of blood perfusion.

The aim of the present study was to evaluate whether hyperbaric oxygen (HBO) environment, with increased oxygen supply to the brain, will enable better performance of complex and/or multiple activities.

Methods: a prospective, double blind randomized control, cross over trial including healthy volunteers. Participants were asked to perform a cognitive task, a motor task and a simultaneous cognitive-motor task (multi-tasking). Participants were randomized to perform the tasks at 2 environments: (a) normobaric air (1ATA 21% oxygen) (b) HBO (2ATA 100% oxygen). Two weeks later participants were crossed to the alternative environment. Blinding of the normobaric environment was achieved in the same chamber with masks on while hyperbaric sensation was simulated by increasing pressure in the first minute and gradually decreasing to normobaric environment prior to tasks performance.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 24
• Est. completion date: March 25, 2017
• Est. primary completion date: November 30, 2016
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• healthy volunteers,

• minimum of 12 years of formal education

Exclusion Criteria:

• any inner ear pathologies,

• any lung disease,

• any mental or physical limitation of participat in going into oxygen chamber environment

Related Conditions & MeSH terms

• Cognitive Change

Intervention

Device:
• Hyperbaric oxygen
Breathing 100% oxygen at 2ATA in the hyperbaric chamber
• Hyperbaric chamber, normal air
Hyperbaric chamber with normal air

Locations

Country	Name	City	State
Israel	Assaf-Harofeh Medical Center	Zerifin

Sponsors (1)

Lead Sponsor	Collaborator
Assaf-Harofeh Medical Center

Country where clinical trial is conducted

Israel, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Cognitive/Attention Symbol-Digit Modality Test (SDMT)	Three different forms of the SDMT were used in each evaluation session. The first was a try-out for the test, ensuring understanding of the task. The second tests the ability to per-form an individual task. The third form was used together with the motor test for examin-ing dual task performance. Standard administration procedures were followed as indicat-ed in the test manual. The score of the test is the number of correct substitutions during 90-second interval.	45 minutes
Primary	Motor task: transferring of beans	Motor performance was evaluated by the Motor Assessment Scale test (MAS) - transfer-ring units of beans one by one between two tea cups an arm length away.	45 minutes